PMID- 1578806
OWN - NLM
STAT- MEDLINE
DCOM- 19920611
LR  - 20200928
IS  - 0446-6586 (Print)
IS  - 0446-6586 (Linking)
VI  - 89
IP  - 3
DP  - 1992 Mar
TI  - [Hepatic receptor imaging with Tc-99m GSA: estimates of liver function in acute 
      liver disease].
PG  - 616-26
AB  - Technetium-99m galactosyl human serum albumin (TcGSA) is a synthesized 
      radiolabeled analog ligand to asialoglycoprotein receptor, which resides only at 
      a mammalian hepatocyte. TcGSA studies were performed on 16 patients with various 
      acute liver disease and 3 controls with normal livers. Dynamic data were obtained 
      by a gamma camera during 35 minutes after an intravenous injection of 3 mg (185 
      MBq) of TcGSA. The parameters of TcGSA time activity curves were obtained by 
      dividing radioactivity of the liver by that of the liver plus heart at 15 min 
      (Receptor Index), and by dividing radioactivity of the liver at 15 min by that at 
      3 min post injection (Clearance Index). The two parameters correlated well with 
      prothrombin time, clinically estimated staging, and severity of acute liver 
      disease. We have concluded that liver function study by the newly developed 
      receptor imaging with TcGSA can be a sensitive and promising tool in estimating 
      the severity and prognosis of acute liver disease.
FAU - Kudo, M
AU  - Kudo M
AD  - Division of Gastroenterology, Kobe City General Hospital.
FAU - Ikekubo, K
AU  - Ikekubo K
FAU - Todo, A
AU  - Todo A
FAU - Mimura, J
AU  - Mimura J
FAU - Okabe, Y
AU  - Okabe Y
FAU - Kashida, H
AU  - Kashida H
FAU - Hirasa, M
AU  - Hirasa M
FAU - Ibuki, Y
AU  - Ibuki Y
FAU - Tomita, S
AU  - Tomita S
FAU - Komori, H
AU  - Komori H
AU  - et al.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Shokakibyo Gakkai Zasshi
JT  - Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
JID - 2984683R
RN  - 0 (Asialoglycoprotein Receptor)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Technetium Tc 99m Aggregated Albumin)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asialoglycoprotein Receptor
MH  - Female
MH  - Humans
MH  - Liver/metabolism/*physiopathology
MH  - Liver Diseases/diagnostic imaging/*physiopathology
MH  - Liver Function Tests
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Radionuclide Imaging
MH  - Receptors, Immunologic/*metabolism
MH  - *Technetium Tc 99m Aggregated Albumin
EDAT- 1992/03/01 00:00
MHDA- 1992/03/01 00:01
CRDT- 1992/03/01 00:00
PHST- 1992/03/01 00:00 [pubmed]
PHST- 1992/03/01 00:01 [medline]
PHST- 1992/03/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Shokakibyo Gakkai Zasshi. 1992 Mar;89(3):616-26.