PMID- 15789215
OWN - NLM
STAT- MEDLINE
DCOM- 20060706
LR  - 20181113
IS  - 0256-7040 (Print)
IS  - 0256-7040 (Linking)
VI  - 22
IP  - 1
DP  - 2006 Jan
TI  - Endoscopic biopsy interpretation difficulties in a congenital diffuse 
      intracranial teratoma.
PG  - 84-9
AB  - INTRODUCTION: Congenital brain tumours are a rare entity that is nowadays often 
      already recognised during pregnancy by ultrasound (US) and magnetic resonance 
      (MR). Even though the definitive diagnosis is usually achieved by means of 
      histological studies, in some cases the diagnosis may remain uncertain because of 
      the malformative origin of this type of tumour. CASE REPORT: We describe a 
      patient with a diffuse congenital intracranial mass diagnosed by intrauterine US 
      and foetal MR performed to further evaluate the lesion and the associated foetal 
      hydrocephalus. After delivery by caesarean section, an endoscopic biopsy was 
      performed. Several specimens were obtained and resulted in the diagnosis of 
      primitive neuroectodermal tumour (PNET). Despite polychemotherapy, the tumour 
      continued to enlarge and the patient died at 2 months of age. Post-mortem 
      histological examination of the intracranial mass showed a diffuse intracranial 
      teratoma. CONCLUSION: Endoscopic biopsy specimen examination resulted in a 
      diagnosis that was not confirmed by post-mortem findings. The scarce 
      differentiation of teratoma components and their high variability in 
      histomorphology as well as the huge size of the tumoral mass may limit the 
      interpretation of endoscopic biopsy specimens, even when multiple and obtained 
      from different areas.
FAU - Di Rocco, Federico
AU  - Di Rocco F
AD  - Division of Pediatric Neurosurgery, Women's and Children's Medical Center, Jikei 
      University, 3-25-8, Nishi-Shinbashi, 105-8461 Tokyo, Japan.
FAU - Nonaka, Yuichiro
AU  - Nonaka Y
FAU - Hamada, Hideo
AU  - Hamada H
FAU - Yoshino, Masami
AU  - Yoshino M
FAU - Nakazaki, Hiromichi
AU  - Nakazaki H
FAU - Oi, Shizuo
AU  - Oi S
LA  - eng
PT  - Journal Article
DEP - 20050323
PL  - Germany
TA  - Childs Nerv Syst
JT  - Child's nervous system : ChNS : official journal of the International Society for 
      Pediatric Neurosurgery
JID - 8503227
SB  - IM
MH  - Biopsy/methods
MH  - Brain Neoplasms/*diagnosis
MH  - *Endoscopes
MH  - Female
MH  - Humans
MH  - Hydrocephalus/complications/pathology
MH  - Infant
MH  - Magnetic Resonance Imaging/methods
MH  - Teratoma/*diagnosis
MH  - Tomography, X-Ray Computed/methods
EDAT- 2005/03/25 09:00
MHDA- 2006/07/11 09:00
CRDT- 2005/03/25 09:00
PHST- 2004/07/20 00:00 [received]
PHST- 2005/03/25 09:00 [pubmed]
PHST- 2006/07/11 09:00 [medline]
PHST- 2005/03/25 09:00 [entrez]
AID - 10.1007/s00381-004-1088-y [doi]
PST - ppublish
SO  - Childs Nerv Syst. 2006 Jan;22(1):84-9. doi: 10.1007/s00381-004-1088-y. Epub 2005 
      Mar 23.