PMID- 15789276
OWN - NLM
STAT- MEDLINE
DCOM- 20050712
LR  - 20221207
IS  - 0947-7349 (Print)
IS  - 0947-7349 (Linking)
VI  - 113
IP  - 3
DP  - 2005 Mar
TI  - Clinical characteristics of type 2 diabetes mellitus in overweight European 
      caucasian adolescents.
PG  - 167-70
AB  - AIM: To present the clinical features of Type 2 diabetes mellitus (T2DM) in 
      overweight European Caucasian children and adolescents. METHODS: We report the 
      clinical characteristics of 16 non-syndromal overweight European Caucasian 
      adolescents with T2DM (10 boys, 6 girls, SDS-BMI in median +2.8, range +1.6 to 
      +3.4) treated in 5 specialised centres for obesity and diabetes. RESULTS: None of 
      the adolescents manifested with ketoacidosis. 13 were asymptomatic (3 adolescents 
      with polyuria), 12 showed features of metabolic syndrome (dyslipidaemia or 
      hypertension), 8 demonstrated acanthosis nigricans and 12 had relatives with 
      T2DM. 11 adolescents were extremely obese and all patients were pubertal. Mean 
      age at diagnosis was 14.2 years (range 11.0 - 16.9). Median insulin was 19 
      microU/ml, insulin resistance index (HOMA) 8.5, C-peptide 2.3 ng/ml, HbA1c 6.9 %, 
      fasting blood glucose 176 mg/dl and blood glucose at 2 hours with the oGTT 229 
      mg/dl at manifestation. Fasting blood glucose and HBA1c were in the normal range 
      in 4 and 6 adolescents respectively, while oGTT always fitted the diagnosis of 
      T2DM. CONCLUSION: Since T2DM occurred in Caucasian overweight adolescents and is 
      frequently asymptomatic, it is essential that clinicians perform diagnostic 
      procedures to identify T2DM in high-risk groups of overweight Caucasian 
      adolescents (extreme obesity, features of metabolic syndrome, relatives with 
      T2DM).
FAU - Reinehr, T
AU  - Reinehr T
AD  - Vestische Kinder- und Jugendklinik, University of Witten-Herdecke, Datteln, 
      Germany. T.Renehr@kinderklinik-datteln.de
FAU - Andler, W
AU  - Andler W
FAU - Kapellen, T
AU  - Kapellen T
FAU - Kiess, W
AU  - Kiess W
FAU - Richter-Unruh, A
AU  - Richter-Unruh A
FAU - Schonau, E
AU  - Schonau E
FAU - Seewi, O
AU  - Seewi O
FAU - Heinze, E
AU  - Heinze E
FAU - Wabitsch, M
AU  - Wabitsch M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Acanthosis Nigricans/etiology
MH  - Adolescent
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/*complications/drug therapy/ethnology/*physiopathology
MH  - Europe
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hyperlipidemias/etiology
MH  - Hypertension/etiology
MH  - Hypoglycemic Agents/therapeutic use
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Male
MH  - Metabolic Syndrome/etiology
MH  - Obesity/*complications/diet therapy/*ethnology
MH  - Polyuria/etiology
MH  - Puberty
MH  - *White People
EDAT- 2005/03/25 09:00
MHDA- 2005/07/13 09:00
CRDT- 2005/03/25 09:00
PHST- 2005/03/25 09:00 [pubmed]
PHST- 2005/07/13 09:00 [medline]
PHST- 2005/03/25 09:00 [entrez]
AID - 10.1055/s-2005-837522 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2005 Mar;113(3):167-70. doi: 10.1055/s-2005-837522.