PMID- 15789753
OWN - NLM
STAT- MEDLINE
DCOM- 20050719
LR  - 20190917
IS  - 0253-6269 (Print)
IS  - 0253-6269 (Linking)
VI  - 28
IP  - 2
DP  - 2005 Feb
TI  - Antinociceptive effect of nicotine in various pain models in the mouse.
PG  - 209-15
AB  - The antinociceptive effect of nicotine administered intracereboventricularly 
      (i.c.v.) or intrathecally (i.t) in several pain models was examined in the 
      present study. We found that i.t. treatment with nicotine (from 5 to 20 g) 
      dose-dependently blocked pain behavior revealed during the second phase, but not 
      during the first phase in the formalin test. In addition, i.c.v. treatment with 
      nicotine (from 0.1 to 10 microg) dose-dependently attenuated pain behavior 
      revealed during both the first and second phases. In addition to the formalin 
      test, nicotine administered i.c.v. or i.t. attenuated acetic acid-induced 
      writhing response. Furthermore, i.c.v. or i.t. administration of nicotine did not 
      cause licking, scratching and biting responses induced by substance P, glutamate, 
      TNF-alpha (100 pg), IL-1beta (100 pg) and INF-gamma (100 pg) injectied i.t. The 
      antinociception induced by supraspinally-administered nicotine appears to be more 
      effective than that resulting from spinally administered nicotine. Our results 
      suggest that nicotine administration induces antinociception by acting on the 
      central nervous system and has differing antinociceptive profiles according to 
      the various pain models.
FAU - Han, Ki-Jung
AU  - Han KJ
AD  - Department of Pharmacology and Institute of Natural Medicine, Hallym University, 
      Gangwon-Do 200-702, Korea.
FAU - Choi, Seong-Soo
AU  - Choi SS
FAU - Lee, Jin-Young
AU  - Lee JY
FAU - Lee, Han-Kyu
AU  - Lee HK
FAU - Shim, Eon-Jeong
AU  - Shim EJ
FAU - Kwon, Min Soo
AU  - Kwon MS
FAU - Seo, Young-Jun
AU  - Seo YJ
FAU - Suh, Hong-Won
AU  - Suh HW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Arch Pharm Res
JT  - Archives of pharmacal research
JID - 8000036
RN  - 0 (Analgesics)
RN  - 0 (Nicotinic Agonists)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - *Analgesics
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Injections, Intraventricular
MH  - Injections, Spinal
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Nicotine/*pharmacology
MH  - Nicotinic Agonists/*pharmacology
MH  - Pain/chemically induced/*drug therapy
MH  - Pain Measurement/drug effects
EDAT- 2005/03/26 09:00
MHDA- 2005/07/20 09:00
CRDT- 2005/03/26 09:00
PHST- 2005/03/26 09:00 [pubmed]
PHST- 2005/07/20 09:00 [medline]
PHST- 2005/03/26 09:00 [entrez]
AID - 10.1007/BF02977717 [doi]
PST - ppublish
SO  - Arch Pharm Res. 2005 Feb;28(2):209-15. doi: 10.1007/BF02977717.