PMID- 15790358
OWN - NLM
STAT- MEDLINE
DCOM- 20050803
LR  - 20071115
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 204
DP  - 2005 Apr
TI  - The regulation and activation of lupus-associated B cells.
PG  - 165-83
AB  - Anti-double-stranded DNA (anti-dsDNA) B cells are regulated in non-autoimmune 
      mice. While some are deleted or undergo receptor editing, a population of 
      anti-dsDNA (VH3H9/V lambda 1) B cells that emigrate into the periphery has also 
      been identified. These cells have an altered phenotype relative to normal B cells 
      in that they have a reduced lifespan, appear developmentally arrested, and 
      localize primarily to the T/B-cell interface in the spleen. This phenotype may be 
      the consequence of immature B cells encountering antigen in the absence of T-cell 
      help. When provided with T-cell help, the anti-dsDNA B cells differentiate into 
      antibody-forming cells. In the context of the autoimmune-prone lpr/lpr or gld/gld 
      mutations, the VH3H9/V lambda 1 anti-dsDNA B cells populate the B-cell follicle 
      and by 12 weeks of age produce serum autoantibodies. The early event of 
      anti-dsDNA B-cell follicular entry, in the absence of autoantibody production, is 
      dependent upon CD4(+) T cells. We hypothesize that control of autoantibody 
      production in young autoimmune-prone mice may be regulated by the 
      counterbalancing effect of T-regulatory (T(reg)) cells. Consistent with this 
      model, we have demonstrated that T(reg) cells are able to prevent autoantibody 
      production induced by T-cell help. Additional studies are aimed at investigating 
      the mechanisms of this suppression as well as probing the impact of distinct 
      forms of T-cell-dependent and -independent activation on anti-dsDNA B cells.
FAU - Fields, Michele L
AU  - Fields ML
AD  - The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
FAU - Hondowicz, Brian D
AU  - Hondowicz BD
FAU - Wharton, Gina N
AU  - Wharton GN
FAU - Adair, Brigette S
AU  - Adair BS
FAU - Metzgar, Michele H
AU  - Metzgar MH
FAU - Alexander, Shawn T
AU  - Alexander ST
FAU - Caton, Andrew J
AU  - Caton AJ
FAU - Erikson, Jan
AU  - Erikson J
LA  - eng
GR  - 2T32AI007518/AI/NIAID NIH HHS/United States
GR  - AI32137/AI/NIAID NIH HHS/United States
GR  - AR47913/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/genetics/immunology/pathology
MH  - B-Lymphocytes/*immunology/metabolism/pathology
MH  - DNA/immunology
MH  - Humans
MH  - Lupus Vulgaris/genetics/*immunology/pathology
MH  - *Lymphocyte Activation
MH  - T-Lymphocytes/immunology/metabolism/pathology
RF  - 125
EDAT- 2005/03/26 09:00
MHDA- 2005/08/04 09:00
CRDT- 2005/03/26 09:00
PHST- 2005/03/26 09:00 [pubmed]
PHST- 2005/08/04 09:00 [medline]
PHST- 2005/03/26 09:00 [entrez]
AID - IMR238 [pii]
AID - 10.1111/j.0105-2896.2005.00238.x [doi]
PST - ppublish
SO  - Immunol Rev. 2005 Apr;204:165-83. doi: 10.1111/j.0105-2896.2005.00238.x.