PMID- 15790931
OWN - NLM
STAT- MEDLINE
DCOM- 20051221
LR  - 20231212
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Linking)
VI  - 25
IP  - 6
DP  - 2005 Jun
TI  - Elevated interleukin-18 levels are associated with the metabolic syndrome 
      independent of obesity and insulin resistance.
PG  - 1268-73
AB  - OBJECTIVE: Activated innate immunity is thought to be involved in the 
      pathogenesis of metabolic syndrome and type 2 diabetes. Interleukin-18 (IL-18) is 
      a pleiotropic proinflammatory cytokine with important regulatory functions in the 
      innate immune response. We sought to determine whether an elevated IL-18 
      concentration was a risk predictor for metabolic syndrome in a community 
      population independent of obesity and hyperinsulinemia. METHODS AND RESULTS: A 
      representative general population, aged 27 to 77 years, without clinical diabetes 
      was studied for clinical and biochemical risk factors for metabolic syndrome. 
      Serum IL-18 concentration measured in 955 subjects correlated with metabolic 
      syndrome traits including body mass index (BMI), waist circumference, 
      triglyceride, high-density lipoprotein (inversely), and fasting glucose and 
      insulin levels (all P<0.001). Mean IL-18 levels rose progressively with the 
      increasing number of metabolic risk factors (ANOVA P<0.001). After adjusting for 
      age, gender, BMI, and insulin levels, increasing IL-18 tertiles were associated 
      with an odds ratio for metabolic syndrome of 1.0, 1.42, and 2.28, respectively (P 
      trend=0.007). The graded risk relation was even stronger in nonobese subjects and 
      not attenuated when adjusted for C-reactive protein and IL-6 levels. CONCLUSIONS: 
      Our findings support the hypothesis that activation of IL-18 is involved in the 
      pathogenesis of the metabolic syndrome.
FAU - Hung, Joseph
AU  - Hung J
AD  - Sir Charles Gairdner Hospital Campus of the Heart Research Institute of Western 
      Australia, and School of Medicine and Pharmacology, University of Western 
      Australia, Nedlands, Perth. jhung@cyllene.uwa.edu.au
FAU - McQuillan, Brendan M
AU  - McQuillan BM
FAU - Chapman, Caroline M L
AU  - Chapman CM
FAU - Thompson, Peter L
AU  - Thompson PL
FAU - Beilby, John P
AU  - Beilby JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050324
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-6)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
CIN - Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):e143. PMID: 16258146
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/immunology
MH  - Female
MH  - Humans
MH  - Insulin Resistance/*immunology
MH  - Interleukin-18/*blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Metabolic Syndrome/blood/*epidemiology/*immunology
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Obesity/blood/*epidemiology/*immunology
MH  - Predictive Value of Tests
MH  - Risk Factors
EDAT- 2005/03/26 09:00
MHDA- 2005/12/22 09:00
CRDT- 2005/03/26 09:00
PHST- 2005/03/26 09:00 [pubmed]
PHST- 2005/12/22 09:00 [medline]
PHST- 2005/03/26 09:00 [entrez]
AID - 01.ATV.0000163843.70369.12 [pii]
AID - 10.1161/01.ATV.0000163843.70369.12 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1268-73. doi: 
      10.1161/01.ATV.0000163843.70369.12. Epub 2005 Mar 24.