PMID- 15791608
OWN - NLM
STAT- MEDLINE
DCOM- 20050419
LR  - 20220330
IS  - 0270-9139 (Print)
IS  - 0270-9139 (Linking)
VI  - 41
IP  - 4
DP  - 2005 Apr
TI  - Impact of hepatitis C on health related quality of life: a systematic review and 
      quantitative assessment.
PG  - 790-800
AB  - Hepatitis C virus (HCV) diminishes health related quality of life (HRQOL), and it 
      is now common to measure HRQOL in clinical trials. We sought to summarize the 
      HRQOL data in HCV, and to establish the minimally clinically important difference 
      (MCID) in HRQOL scores in HCV. We performed a systematic review to identify 
      relevant studies, and converted HRQOL data from each study into clinically 
      interpretable statistics. An expert panel used a modified Delphi technique to 
      estimate the MCID in HCV. We found that patients with HCV scored lower than 
      controls across all scales of the SF-36. Patients achieving sustained virological 
      response (SVR) scored higher across all scales versus patients without SVR, 
      especially in the physical health domains. HRQOL differences did not correspond 
      with differences in liver histology or ALT levels. Based upon the published data, 
      the expert panel concluded that the SF-36 vitality scale was most relevant in 
      patients with HCV, and generated a mean MCID of 4.2 points on this scale. In 
      conclusion, patients with HCV have a clinically significant decrement in HRQOL 
      versus controls, and physical HRQOL improves in patients achieving SVR but not in 
      those without SVR. The data further suggest that traditional outcomes fail to 
      capture the full spectrum of illness related to chronic HCV. A difference of 4.2 
      points on the SF-36 vitality scale can be used as an estimate of the MCID in HCV, 
      and this value may be used as the basis for power calculations in clinical trials 
      evaluating HRQOL. Supplementary material for this article can be found on the 
      HEPATOLOGY website 
      (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html).
FAU - Spiegel, Brennan M R
AU  - Spiegel BM
AD  - Division of Gastroenterology, VA Greater Los Angeles Healthcare System, USA.
FAU - Younossi, Zobair M
AU  - Younossi ZM
FAU - Hays, Ron D
AU  - Hays RD
FAU - Revicki, Dennis
AU  - Revicki D
FAU - Robbins, Sean
AU  - Robbins S
FAU - Kanwal, Fasiha
AU  - Kanwal F
LA  - eng
GR  - AG-02-004/AG/NIA NIH HHS/United States
GR  - P20-MD00148-01/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
SB  - IM
MH  - Case-Control Studies
MH  - Delphi Technique
MH  - *Health Status
MH  - Hepatitis C/*physiopathology/psychology/therapy/virology
MH  - Humans
MH  - Neuropsychological Tests
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - Viral Load
RF  - 49
EDAT- 2005/03/26 09:00
MHDA- 2005/04/20 09:00
CRDT- 2005/03/26 09:00
PHST- 2005/03/26 09:00 [pubmed]
PHST- 2005/04/20 09:00 [medline]
PHST- 2005/03/26 09:00 [entrez]
AID - 10.1002/hep.20659 [doi]
PST - ppublish
SO  - Hepatology. 2005 Apr;41(4):790-800. doi: 10.1002/hep.20659.