PMID- 15791865
OWN - NLM
STAT- MEDLINE
DCOM- 20060518
LR  - 20191109
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 24
IP  - 6
DP  - 2004
TI  - Expression of hypoxia inducible factor-1alpha and its relationship to apoptosis 
      and proliferation in human laryngeal squamous cell carcinoma.
PG  - 636-8
AB  - To investigate the expression of hypoxia inducible factor-1 alpha (HIF-1alpha) 
      and its relationship to apoptosis and proliferation in laryngeal squamous cell 
      carcinoma (LSCC), immunohistochemical method was used to detect the expression of 
      HIF-1alpha and PCNA. Tunnel technique was used to detect in situ cell apoptosis 
      in LSCC. Our results showed that the expression of HIF-1alpha was related to the 
      clinical stages of cancer and lymph node metastasis (P<0.05). The relationship 
      between HIF-1alpha and PCNA was statistically significant (P<0.05) and no 
      relationship was found between HIF-1alpha and apoptosis (P>0.05) It is concluded 
      that HIF-1alpha plays a role in the carcinogenesis of laryngeal carcinoma and is 
      correlated with proliferation, but bears no relationship with the apoptosis of 
      tumor cells in LSCC.
FAU - Yu, Linlin
AU  - Yu L
AD  - Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Liu, Yang
AU  - Liu Y
FAU - Cui, Yonghua
AU  - Cui Y
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Proliferating Cell Nuclear Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apoptosis/*physiology
MH  - Carcinoma, Squamous Cell/*metabolism/secondary
MH  - Cell Proliferation
MH  - Female
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*biosynthesis/genetics
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymph Nodes/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Proliferating Cell Nuclear Antigen/biosynthesis/genetics
MH  - Tumor Cells, Cultured
EDAT- 2005/03/29 09:00
MHDA- 2006/05/19 09:00
CRDT- 2005/03/29 09:00
PHST- 2005/03/29 09:00 [pubmed]
PHST- 2006/05/19 09:00 [medline]
PHST- 2005/03/29 09:00 [entrez]
AID - 10.1007/BF02911379 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2004;24(6):636-8. doi: 10.1007/BF02911379.