PMID- 15792363
OWN - NLM
STAT- MEDLINE
DCOM- 20050711
LR  - 20190818
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 270
IP  - 1-2
DP  - 2005 Feb
TI  - Effect of chronic administration of lignan complex isolated from flaxseed on the 
      hemopoietic system.
PG  - 139-45
AB  - Lignan complex has been isolated from flaxseed. It has been shown to reduce serum 
      lipids and the extent of hypercholesterolemic atherosclerosis. However, it is not 
      known whether the chronic use of lignan complex has any adverse effects on the 
      hemopoietic system. The effects of lignan complex (40 mg/kg body wt orally daily 
      for 2 months) on the red blood cells (RBC) count, mean corpuscular volume (MCV), 
      red cell distribution width (RDW), hematocrit (Hct), hemoglobin (Hb), mean 
      corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), 
      and counts of white blood cell (WBC), granulocytes, lymphocytes, monocytes and 
      platelet, and platelet volume were investigated in normo- and 
      hypercholesterolemic rabbits. The results show that lignan complex had no adverse 
      effects of counts of RBC, WBC, granulocytes, lymphocytes, monocytes and platelet 
      in both the normo- and hyper-cholesterolemic rabbits. The values for MCV, RDW, 
      Hct, Hb, MCH, MCHC, and platelet volume were similar in lignan complex-treated or 
      untreated normo- and hypercholesterolemic rabbits. It is concluded that chronic 
      use of lignan complex had no adverse effects on the hemopoietic system.
FAU - Prasad, Kailash
AU  - Prasad K
AD  - Department of Physiology, College of Medicine, University of Saskatchewan, 
      Saskatoon, Canada. prasadk@usask.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Butylene Glycols)
RN  - 0 (Hemoglobins)
RN  - 0 (Lignans)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - M8QRJ7JEJH (secoisolariciresinol)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Blood Platelets/metabolism
MH  - Butylene Glycols/pharmacology
MH  - Cholesterol/metabolism
MH  - Erythrocyte Indices
MH  - Erythrocytes/cytology
MH  - Female
MH  - Flax/*metabolism
MH  - Granulocytes/metabolism
MH  - Hematocrit
MH  - Hematopoietic Stem Cells/*cytology/*drug effects
MH  - Hemoglobins/metabolism
MH  - Leukocytes/cytology
MH  - Lignans/administration & dosage/*chemistry/pharmacology
MH  - Lipid Metabolism
MH  - Lymphocytes/metabolism
MH  - Monocytes/metabolism
MH  - Platelet Count
MH  - Rabbits
MH  - Time Factors
EDAT- 2005/03/29 09:00
MHDA- 2005/07/12 09:00
CRDT- 2005/03/29 09:00
PHST- 2005/03/29 09:00 [pubmed]
PHST- 2005/07/12 09:00 [medline]
PHST- 2005/03/29 09:00 [entrez]
AID - 10.1007/s11010-005-5283-2 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2005 Feb;270(1-2):139-45. doi: 10.1007/s11010-005-5283-2.