PMID- 15794131
OWN - NLM
STAT- MEDLINE
DCOM- 20050414
LR  - 20220309
IS  - 1447-6959 (Print)
IS  - 1447-073X (Linking)
VI  - 80
IP  - 1
DP  - 2005 Mar
TI  - Oncostatin M in the development of the nervous system.
PG  - 53-9
AB  - Oncostatin M (OSM) is a member of the interleukin-6 family of cytokines. Of these 
      cytokines, OSM is closely related structually, genetically and functionally to 
      leukemia inhibitory factor. However, OSM-specific biological activities have been 
      reported in hematopoiesis and liver development. Recently, we have demonstrated 
      OSM-specific activities in the nervous systems. In the adult central nervous 
      system (CNS), OSM receptor (OSMR) beta was observed in meningeal cells of pia 
      mater, epithelial cells of the choroid plexus and olfactory astrocyte-like glia 
      surrounding the glomeruli of the olfactory bulb. In the CNS of neonatal mice, 
      OSMRbeta was also expressed in the ventral subnucleus of the hypoglossal nucleus, 
      but disappeared at post-natal day (P) 14. In contrast with the CNS, OSMRbeta was 
      strongly expressed in small-sized non-peptidergic neurons of the dorsal root 
      ganglia (DRG) and trigeminal ganglia (TG). Interestingly, all OSMRbeta-positive 
      neurons in these ganglia also expressed both TRPV1 (a vanilloid receptor) and 
      P2X3 (a purinergic receptor). In OSM-deficient mice, TRPV1/P2X3/OSMRbeta 
      triple-positive neurons were significantly decreased. Consistent with such 
      histological findings, OSM-deficient mice exhibited a reduction in responses to 
      various stimuli, including mechanical and thermal stimuli. These findings suggest 
      an important role for OSM in the development of a subset of nociceptive neurons.
FAU - Morikawa, Yoshihiro
AU  - Morikawa Y
AD  - Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, 
      Japan. yoshim@wakayama-med.ac.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Japan
TA  - Anat Sci Int
JT  - Anatomical science international
JID - 101154140
RN  - 0 (Growth Inhibitors)
RN  - 0 (OSM protein, human)
RN  - 0 (Osm protein, mouse)
RN  - 0 (Peptides)
RN  - 106956-32-5 (Oncostatin M)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Animals, Newborn
MH  - Central Nervous System/*embryology/metabolism
MH  - Growth Inhibitors/chemistry/genetics/*metabolism
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - Nociceptors/embryology/metabolism
MH  - Oncostatin M
MH  - *Organogenesis
MH  - Peptides/chemistry/genetics/*metabolism
MH  - Sequence Alignment
RF  - 51
EDAT- 2005/03/30 09:00
MHDA- 2005/04/15 09:00
CRDT- 2005/03/30 09:00
PHST- 2005/03/30 09:00 [pubmed]
PHST- 2005/04/15 09:00 [medline]
PHST- 2005/03/30 09:00 [entrez]
AID - 10.1111/j.1447-073x.2005.00100.x [doi]
PST - ppublish
SO  - Anat Sci Int. 2005 Mar;80(1):53-9. doi: 10.1111/j.1447-073x.2005.00100.x.