PMID- 15796050
OWN - NLM
STAT- MEDLINE
DCOM- 20050630
LR  - 20151119
IS  - 0047-1860 (Print)
IS  - 0047-1860 (Linking)
VI  - 53
IP  - 2
DP  - 2005 Feb
TI  - [Oxidative stress related diseases and biopyrrins].
PG  - 155-9
AB  - Reactive oxygen species (ROS) cause damage to the structure and function of 
      tissues. Therefore tissues have systems that eliminate ROS. Bilirubin is one 
      antioxidant that reacts with ROS to produce oxidative metabolites. Biopyrrins are 
      one of the metabolites, the level of which in urine reflects oxidative stress. 
      They are measured by non-competitive inhibition ELISA that employs anti-bilirubin 
      antibody (24G7) and the results are corrected for the urinary concentration of 
      cereatinine. Some reports suggested that psychological stress increased oxidative 
      stress markers. Urinary biopyrrins were also elevated by speech stress, and the 
      subjective stress score recorded by the speakers correlated with the level. The 
      result suggests that bilirubin might eliminate ROS generated by psychological 
      stress. From the beginning of the study of biopyrrins, their urinary level has 
      been known to be increased by surgical stress. Furthermore, it was significantly 
      higher in a major operation patient group than in a minor one, and correlated 
      with operation duration. Sepsis increased the level in surgical patients. 
      Ischemia-reperfusion elevates ROS and, as a result, biopyrrin production. An 
      increase in urinary biopyrrins was observed in a coronary spastic angina group 
      after a spasm provocation test, and the level in myocardial infarction patients 
      with NYHA (New York Heart Association) classification became higher. Correlation 
      between urinary biopyrrins and plasma B-type natriuretic peptide (BNP) was also 
      reported. Research that determines the structures of biopyrrins and their 
      clinical application are in progress.
FAU - Shioji, Izuru
AU  - Shioji I
AD  - Shino-Test Corporation, R&D Dept., Sagamihara.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Byori
JT  - Rinsho byori. The Japanese journal of clinical pathology
JID - 2984781R
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - Antioxidants
MH  - Bilirubin/analogs & derivatives/immunology/*physiology
MH  - Biomarkers/urine
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Humans
MH  - Myocardial Reperfusion Injury/diagnosis
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species
MH  - Sepsis/diagnosis
MH  - Stress, Physiological/*diagnosis
MH  - Stress, Psychological/*diagnosis
RF  - 16
EDAT- 2005/03/31 09:00
MHDA- 2005/07/01 09:00
CRDT- 2005/03/31 09:00
PHST- 2005/03/31 09:00 [pubmed]
PHST- 2005/07/01 09:00 [medline]
PHST- 2005/03/31 09:00 [entrez]
PST - ppublish
SO  - Rinsho Byori. 2005 Feb;53(2):155-9.