PMID- 15797513
OWN - NLM
STAT- MEDLINE
DCOM- 20050613
LR  - 20220408
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 26
IP  - 4
DP  - 2005 Apr
TI  - Cellular ligands of activating NK receptors.
PG  - 221-6
AB  - Human natural killer (NK) cells are equipped with a series of surface receptors 
      that recognise different cellular ligands on potential target cells. Some of 
      these ligands [e.g. human leukocyte antigen (HLA) class I] prevent an NK-mediated 
      attack by interacting with inhibitory NK receptors (e.g. killer Ig-like 
      receptors). Other ligands interact with activating NK receptors that, once 
      engaged, induce both cytotoxicity and lymphokine release. Tumour transformation 
      (or viral infection) frequently results in downregulation of surface HLA class I 
      molecules together with upregulation or de novo expression of ligands of 
      triggering NK receptors. Thus, transformed cells can become highly susceptible to 
      NK-mediated lysis. However, although NK cells use different means to identify and 
      fight target cells, target cells have various strategies to hide themselves, and 
      disarm or even confuse the immune system.
FAU - Bottino, Cristina
AU  - Bottino C
AD  - Istituto Giannina Gaslini, Largo G. Gaslini 5, 16147 Genova, Italy. 
      Cristina.Bottino@unige.it
FAU - Castriconi, Roberta
AU  - Castriconi R
FAU - Moretta, Lorenzo
AU  - Moretta L
FAU - Moretta, Alessandro
AU  - Moretta A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD226 antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Ligands)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Natural Killer Cell)
SB  - IM
MH  - Antigens, Differentiation, T-Lymphocyte/metabolism
MH  - Histocompatibility Antigens Class I/metabolism
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Ligands
MH  - Models, Immunological
MH  - Neoplasms/immunology
MH  - Receptors, Immunologic/*metabolism
MH  - Receptors, Natural Killer Cell
RF  - 73
EDAT- 2005/03/31 09:00
MHDA- 2005/06/14 09:00
CRDT- 2005/03/31 09:00
PHST- 2005/03/31 09:00 [pubmed]
PHST- 2005/06/14 09:00 [medline]
PHST- 2005/03/31 09:00 [entrez]
AID - S1471-4906(05)00046-3 [pii]
AID - 10.1016/j.it.2005.02.007 [doi]
PST - ppublish
SO  - Trends Immunol. 2005 Apr;26(4):221-6. doi: 10.1016/j.it.2005.02.007.