PMID- 15797745
OWN - NLM
STAT- MEDLINE
DCOM- 20050628
LR  - 20161124
IS  - 1053-2498 (Print)
IS  - 1053-2498 (Linking)
VI  - 24
IP  - 4
DP  - 2005 Apr
TI  - Tumor necrosis factor gene polymorphism and cardiac allograft vasculopathy.
PG  - 433-8
AB  - BACKGROUND: Cardiac allograft vasculopathy (CAV) limits survival after cardiac 
      transplantation. Tumor necrosis factor-alpha (TNF-alpha) may be a key factor in 
      the development of CAV. Two bi-allelic polymorphisms associated with high 
      TNF-alpha production have been identified in the TNF gene locus, TNFA1/2, at 
      position -308 and TNFB1/2 at +252. We hypothesized that recipient TNFA2 and TNFB2 
      homozygosity is associated with the development of CAV after heart 
      transplantation. METHODS: TNF gene polymorphisms were analyzed by multiplex 
      fluorescent solid-phase mini-sequencing in 70 cardiac transplant recipients. 
      Recipients homozygous for TNFA2 or TNFB2 (Group A, n = 29) were compared with 
      recipients heterozygous or homozygous for TNFA1 and TNFB1 (Group B, n = 41). 
      Coronary arteriography was performed annually or when indicated. Cumulative 
      freedom from CAV and survival was calculated according to the Kaplan-Meier test. 
      RESULTS: Mean follow-up was 3.8 +/- 0.3 years. In Group A, 11 of 29 recipients 
      (38%) developed CAV compared with 9 of 41 (22%) in Group B (p = 0.12). Cumulative 
      freedom from CAV at 3 years was 42% in Group A and 80% in Group B (p = 0.043). In 
      Group A, 11 of 29 recipients (38%) died during follow-up compared with 4 of 41 
      (10%) in Group B (p = 0.006). Cumulative survival at 3 years was 72% in Group A 
      and 93% in Group B (p = 0.003). CONCLUSIONS: The results suggest that TNFA2 and 
      TNFB2 allele homozygosity is associated with cardiac allograft vasculopathy and 
      mortality in heart transplant recipients.
FAU - Ternstrom, Lisa
AU  - Ternstrom L
AD  - Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Goteborg, 
      Sweden.
FAU - Jeppsson, Anders
AU  - Jeppsson A
FAU - Ricksten, Anne
AU  - Ricksten A
FAU - Nilsson, Folke
AU  - Nilsson F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
RN  - 0 (Genetic Markers)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*blood/diagnostic imaging/etiology
MH  - Coronary Vessels/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Frequency
MH  - Genetic Markers
MH  - Graft Rejection/blood/prevention & control
MH  - Graft Survival/genetics
MH  - Heart Transplantation/*adverse effects/mortality
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Prospective Studies
MH  - Survival Rate
MH  - Transplantation, Homologous
MH  - Tumor Necrosis Factor-alpha/biosynthesis/*genetics
EDAT- 2005/03/31 09:00
MHDA- 2005/06/29 09:00
CRDT- 2005/03/31 09:00
PHST- 2003/11/03 00:00 [received]
PHST- 2004/02/15 00:00 [revised]
PHST- 2004/02/24 00:00 [accepted]
PHST- 2005/03/31 09:00 [pubmed]
PHST- 2005/06/29 09:00 [medline]
PHST- 2005/03/31 09:00 [entrez]
AID - S1053249804002116 [pii]
AID - 10.1016/j.healun.2004.02.019 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2005 Apr;24(4):433-8. doi: 10.1016/j.healun.2004.02.019.