PMID- 15799583
OWN - NLM
STAT- MEDLINE
DCOM- 20050505
LR  - 20190716
IS  - 0001-6489 (Print)
IS  - 0001-6489 (Linking)
VI  - 125
IP  - 1
DP  - 2005 Jan
TI  - CYP17 and tumor necrosis factor-alpha gene polymorphisms are associated with risk 
      of oral cancer in Chinese patients in Taiwan.
PG  - 96-9
AB  - CONCLUSION: Patients who carry the T/T homozygote of CYP17 C/T gene polymorphism 
      may have a higher risk of developing oral cancer. OBJECTIVE: Cancer of the oral 
      cavity is the most commonly seen malignancy in Taiwan, and its rising incidence 
      poses a formidable challenge to oncologists. The CYP17 gene encodes P450c17alpha, 
      an enzyme involved in the metabolism of steroid hormones. Tumor necrosis 
      factor-alpha (TNF-alpha) is one of the cytokines produced by macrophages, and its 
      function has been postulated to play a role in cancer formation. We investigated 
      whether polymorphisms of CYP17 and TNF-alpha genes are associated with oral 
      cancer. MATERIAL AND METHODS: Polymorphisms of CYP17 and TNF-alpha genes were 
      detected by polymerase chain reaction-based restriction analysis in 137 patients 
      with oral cancer and 102 normal controls. RESULTS: The results for the CYP17 gene 
      revealed a significant difference between oral cancer patients and normal 
      controls (p =0.0063), but there was no significant difference for the TNF-alpha 
      gene (p =0.4753).
FAU - Chen, Wei-Cheng
AU  - Chen WC
AD  - Department of Medical Genetics, China Medical University, Taichung, Taiwan.
FAU - Tsai, Ming-Hsui
AU  - Tsai MH
FAU - Wan, Lei
AU  - Wan L
FAU - Chen, Wen-Chi
AU  - Chen WC
FAU - Tsai, Chang-Hai
AU  - Tsai CH
FAU - Tsai, Fuu-Jen
AU  - Tsai FJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (DNA Primers)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.14.14.19 (Steroid 17-alpha-Hydroxylase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - China/ethnology
MH  - DNA Primers/genetics
MH  - Female
MH  - Gene Expression/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mouth Neoplasms/ethnology/genetics/metabolism
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/*genetics
MH  - Risk Factors
MH  - Steroid 17-alpha-Hydroxylase/*genetics
MH  - Taiwan
MH  - Tumor Necrosis Factor-alpha/*genetics/*metabolism
EDAT- 2005/04/01 09:00
MHDA- 2005/05/06 09:00
CRDT- 2005/04/01 09:00
PHST- 2005/04/01 09:00 [pubmed]
PHST- 2005/05/06 09:00 [medline]
PHST- 2005/04/01 09:00 [entrez]
AID - 10.1080/00016480410016919 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2005 Jan;125(1):96-9. doi: 10.1080/00016480410016919.