PMID- 15801034 OWN - NLM STAT- MEDLINE DCOM- 20050711 LR - 20151119 IS - 0315-162X (Print) IS - 0315-162X (Linking) VI - 32 IP - 4 DP - 2005 Apr TI - Proliferative lupus nephritis and leukocytoclastic vasculitis during treatment with etanercept. PG - 740-3 AB - Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine. Agents that neutralize TNF-alpha are effective in the treatment of disorders such as rheumatoid arthritis, juvenile rheumatoid arthritis (JRA), spondyloarthropathies, and inflammatory bowel disease. TNF-alpha antagonist therapy has been associated with the development of antinuclear antibodies (ANA) and double-stranded DNA (dsDNA) antibodies, as well as the infrequent development of systemic lupus erythematosus (SLE)-like disease. We describe the first case of biopsy-confirmed proliferative lupus nephritis and leukocytoclastic vasculitis in a patient treated with etanercept for JRA. FAU - Mor, Adam AU - Mor A AD - Division of Rheumatology, Department of Medicine, New York University School of Medicine/Hospital for Joint Diseases, New York, New York, USA. mora01@med.nyu.edu FAU - Bingham, Clifton O 3rd AU - Bingham CO 3rd FAU - Barisoni, Laura AU - Barisoni L FAU - Lydon, Eileen AU - Lydon E FAU - Belmont, H Michael AU - Belmont HM LA - eng PT - Case Reports PT - Journal Article PL - Canada TA - J Rheumatol JT - The Journal of rheumatology JID - 7501984 RN - 0 (Antirheumatic Agents) RN - 0 (Immunoglobulin G) RN - 0 (Receptors, Tumor Necrosis Factor) RN - 0 (Recombinant Fusion Proteins) RN - OP401G7OJC (Etanercept) SB - IM EIN - J Rheumatol. 2014 Nov;41(11):2336. Bingham, Clifton 3rd [corrected to Bingham, Clifton O 3rd] MH - Adult MH - Antirheumatic Agents/*adverse effects/immunology MH - Arthritis, Juvenile/*complications/drug therapy MH - Disease-Free Survival MH - Etanercept MH - Female MH - Humans MH - Immunocompromised Host MH - Immunoglobulin G/*adverse effects/immunology MH - Lupus Nephritis/*chemically induced/immunology/pathology MH - Receptors, Tumor Necrosis Factor/immunology MH - Recombinant Fusion Proteins/*adverse effects/immunology MH - Vasculitis, Leukocytoclastic, Cutaneous/*chemically induced/immunology/pathology MH - Withholding Treatment EDAT- 2005/04/01 09:00 MHDA- 2005/07/12 09:00 CRDT- 2005/04/01 09:00 PHST- 2005/04/01 09:00 [pubmed] PHST- 2005/07/12 09:00 [medline] PHST- 2005/04/01 09:00 [entrez] AID - 0315162X-32-740 [pii] PST - ppublish SO - J Rheumatol. 2005 Apr;32(4):740-3.