PMID- 15802338
OWN - NLM
STAT- MEDLINE
DCOM- 20051222
LR  - 20130523
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 25
IP  - 4
DP  - 2005 Apr
TI  - Phenotypic characterisation of alveolar macrophages and peripheral blood 
      monocytes in COPD.
PG  - 647-52
AB  - Alveolar macrophages (AM) participate actively in the inflammatory response that 
      characterises chronic obstructive pulmonary disease (COPD). The present study 
      investigated potential changes in AM phenotypes in patients with COPD. Using flow 
      cytometry, the surface expression of receptors implicated in phagocytosis (CD44, 
      CD36, CD51, CD61, CD14), antigen-presenting capacity (human leukocyte antigen 
      (HLA)-DR), costimulatory molecules (CD80, CD86, CD40) and complement receptor 
      type 3 were assessed in AM from 18 patients with COPD, 14 smokers with normal 
      lung function and nine nonsmokers. When compared to smokers with normal lung 
      function and nonsmokers, the surface expression of HLA-DR and CD80 was lower in 
      AM of patients with COPD. In addition, these patients had a higher percentage of 
      AM with a low level surface expression of CD44. There did not appear to be any 
      difference in the other receptors studied in AM between the three groups. The 
      expression of all these receptors in peripheral blood monocytes also did not 
      differ between groups. In conclusion, these observations suggest that the 
      cell-mediated immune function of alveolar macrophages can be reduced in chronic 
      obstructive pulmonary disease, and that this is a local rather than a systemic 
      event.
FAU - Pons, A R
AU  - Pons AR
AD  - Serveis de Analisis Clinics, Pneumologia, Hospital Universitari Son Dureta, 
      Institut Universitari de Investigacions en Ciencies de la Salut (IUNICS), Palma 
      de Mallorca, Spain.
FAU - Noguera, A
AU  - Noguera A
FAU - Blanquer, D
AU  - Blanquer D
FAU - Sauleda, J
AU  - Sauleda J
FAU - Pons, J
AU  - Pons J
FAU - Agusti, A G N
AU  - Agusti AG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Humans
MH  - Macrophages/*immunology
MH  - Middle Aged
MH  - Monocytes/*immunology
MH  - Phenotype
MH  - Pulmonary Alveoli
MH  - Pulmonary Disease, Chronic Obstructive/*blood
MH  - Receptors, Cell Surface/genetics/immunology
EDAT- 2005/04/02 09:00
MHDA- 2005/12/24 09:00
CRDT- 2005/04/02 09:00
PHST- 2005/04/02 09:00 [pubmed]
PHST- 2005/12/24 09:00 [medline]
PHST- 2005/04/02 09:00 [entrez]
AID - 25/4/647 [pii]
AID - 10.1183/09031936.05.00062304 [doi]
PST - ppublish
SO  - Eur Respir J. 2005 Apr;25(4):647-52. doi: 10.1183/09031936.05.00062304.