PMID- 15803806
OWN - NLM
STAT- MEDLINE
DCOM- 20050517
LR  - 20051117
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 24
IP  - 2
DP  - 2005 Mar-Apr
TI  - Loss of chromosome 13 in a case of soft tissue perineurioma.
PG  - 69-76
AB  - Soft tissue perineuriomas are rare mesenchymal tumors that are derived from 
      perineurial cells of the peripheral nerve sheath. Although the histological and 
      immunohistochemical features of soft tissue perineuriomas are well described, 
      little is known regarding the cytogenetic abnormalities in these tumors. Herein, 
      we describe a case of a large (12.2 cm) soft tissue perineurioma that arose in 
      the thigh of a 26-year-old Caucasian female. Histologically, the tumor was 
      composed of a diffuse to fascicular arrangement of spindle cells with bland, 
      elongated nuclei with long, thin, tapering cytoplasmic processes. The 
      immunohistochemical profile was consistent with a perineurial cell origin with 
      expression of epithelial membrane antigen, vimentin, and collagen type IV. 
      Cytogenetic evaluation revealed loss of chromosome 13 as the sole abnormality in 
      the majority of examined cells. In contrast to previous reports, we were unable 
      to demonstrate deletion or structural abnormalities of chromosome 22 by either 
      fluorescence in situ hybridization (FISH) or metaphase cytogenetics. This is the 
      first report of loss of chromosome 13 in soft tissue perineurioma. Although never 
      described in this group of neoplasms, loss of chromosome 13 has been identified 
      in a large number of other soft tissue tumors, particularly sarcomas and 
      malignant peripheral nerve sheath tumors. Herein, we discuss this case and 
      provide a review of the literature.
FAU - Mott, R T
AU  - Mott RT
AD  - Duke University Medical Center, Department of Pathology, Durham, NC 27710, USA. 
      mott0003@mc.duke.edu
FAU - Goodman, B K
AU  - Goodman BK
FAU - Burchette, J L
AU  - Burchette JL
FAU - Cummings, T J
AU  - Cummings TJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
SB  - IM
MH  - Adult
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Female
MH  - Humans
MH  - Nerve Sheath Neoplasms/*genetics/metabolism/pathology
MH  - Soft Tissue Neoplasms/*genetics/metabolism/pathology
MH  - *Thigh
RF  - 65
EDAT- 2005/04/05 09:00
MHDA- 2005/05/18 09:00
CRDT- 2005/04/05 09:00
PHST- 2005/04/05 09:00 [pubmed]
PHST- 2005/05/18 09:00 [medline]
PHST- 2005/04/05 09:00 [entrez]
PST - ppublish
SO  - Clin Neuropathol. 2005 Mar-Apr;24(2):69-76.