PMID- 15805549
OWN - NLM
STAT- MEDLINE
DCOM- 20050919
LR  - 20210217
IS  - 0022-2275 (Print)
IS  - 0022-2275 (Linking)
VI  - 46
IP  - 7
DP  - 2005 Jul
TI  - Genome-wide linkage analyses and candidate gene fine mapping for HDL3 
      cholesterol: the Framingham Study.
PG  - 1416-25
AB  - High density lipoprotein cholesterol (HDL-C) is inversely associated with 
      coronary heart disease and has a genetic component; however, linkage to HDL-C is 
      not conclusive. Subfractions of HDL, such as HDL(3)-C, may be better phenotypes 
      for linkage studies. Using HDL(3)-C levels measured on 907 Framingham Heart Study 
      subjects from 330 families around 1987, we conducted a genome-wide variance 
      components linkage analysis with 401 microsatellite markers spaced approximately 
      10 centimorgan (cM) apart. Nine candidate genes were identified and annotated 
      using a bioinformatics approach in the region of the highest linkage peak. 
      Twenty-eight single nucleotide polymorphisms (SNPs) were selected from these 
      candidate genes, and linkage and family-based association fine mapping were 
      conducted using these SNPs. The highest multipoint log-of-the-odds (LOD) score 
      from the initial linkage analysis was 3.7 at 133 cM on chromosome 6. Linkage 
      analyses with additional SNPs yielded the highest LOD score of 4.0 at 129 cM on 
      chromosome 6. Family-based association analysis revealed that SNP rs2257104 in 
      PLAGL1 at approximately 143 cM was associated with multivariable adjusted HDL(3) 
      (P = 0.03). Further study of the linkage region and exploration of other variants 
      in PLAGL1 are warranted to define the potential functional variants of HDL-C 
      metabolism.
FAU - Yang, Qiong
AU  - Yang Q
AD  - Department of Biostatistics, Boston University, Boston, MA 02118, USA. 
      qyang@bu.edu
FAU - Lai, Chao-Qiang
AU  - Lai CQ
FAU - Parnell, Laurence
AU  - Parnell L
FAU - Cupples, L Adrienne
AU  - Cupples LA
FAU - Adiconis, Xian
AU  - Adiconis X
FAU - Zhu, Yueping
AU  - Zhu Y
FAU - Wilson, Peter W F
AU  - Wilson PW
FAU - Housman, David E
AU  - Housman DE
FAU - Shearman, Amanda M
AU  - Shearman AM
FAU - D'Agostino, Ralph B
AU  - D'Agostino RB
FAU - Ordovas, Jose M
AU  - Ordovas JM
LA  - eng
GR  - 1-38038/PHS HHS/United States
GR  - HL-54776/HL/NHLBI NIH HHS/United States
GR  - N01-HC-25195/HC/NHLBI NIH HHS/United States
GR  - P50-HL-63494/HL/NHLBI NIH HHS/United States
GR  - R01-HL-65230/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050401
PL  - United States
TA  - J Lipid Res
JT  - Journal of lipid research
JID - 0376606
RN  - 0 (DNA Probes)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (Lipoproteins, HDL3)
SB  - IM
MH  - Adult
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 6/*genetics
MH  - Cohort Studies
MH  - DNA Probes
MH  - Female
MH  - *Genetic Linkage
MH  - *Genome, Human
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Lipoproteins, HDL/*genetics
MH  - Lipoproteins, HDL3
MH  - Male
MH  - Massachusetts
MH  - Microsatellite Repeats
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Quantitative Trait Loci
EDAT- 2005/04/05 09:00
MHDA- 2005/09/20 09:00
CRDT- 2005/04/05 09:00
PHST- 2005/04/05 09:00 [pubmed]
PHST- 2005/09/20 09:00 [medline]
PHST- 2005/04/05 09:00 [entrez]
AID - S0022-2275(20)32992-8 [pii]
AID - 10.1194/jlr.M400382-JLR200 [doi]
PST - ppublish
SO  - J Lipid Res. 2005 Jul;46(7):1416-25. doi: 10.1194/jlr.M400382-JLR200. Epub 2005 
      Apr 1.