PMID- 15806584
OWN - NLM
STAT- MEDLINE
DCOM- 20050531
LR  - 20200930
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 135B
IP  - 1
DP  - 2005 May 5
TI  - Toward localizing genes underlying cerebral asymmetry and mental health.
PG  - 79-84
AB  - Genome investigations of autism, attention deficit hyperactivity disorder (ADHD), 
      and dyslexia suggest possible genetic overlap. Atypical cerebral asymmetry (ACA), 
      the absence of the left hemisphere dominance for language, may be a shared 
      phenotype due to genes located in regions of overlap. A binomal test is used to 
      evaluate whether linked regions overlap more than expected by chance for 15 
      genome-wide scans in autism, ADHD, and dyslexia. Significant evidence of linkage 
      overlap (P = 10(-7)) is seen for autism, ADHD, and dyslexia for seven chromosomal 
      regions (2p11-12, 5p13, 7q22-33, 9q33-34, 13q22, 16p13, and 17p11-q11). Linkage 
      analysis of ACA and molecular markers for 270 sibling pairs with ADHD is 
      conducted using the Haseman-Elston statistic. Linkage analysis supports ACA as a 
      shared phenotype with risk genes located on 9q33-34 or 16p13 (P < 0.004). Further 
      support stems from the overlap of these regions in schizophrenia, bipolar 
      illness, specific language impairment (SLI), and handedness, all traits 
      associated with ACA. Autism, ADHD, and dyslexia share regions of linkage overlap 
      and ACA may be a shared phenotype for such genes similar to HLA in autoimmune 
      disease. Because ACA is associated with certain aspects of creativity, such risk 
      genes may also be enhancer genes for creativity.
CI  - Copyright 2005 Wiley-Liss, Inc.
FAU - Smalley, Susan L
AU  - Smalley SL
AD  - Center for Neurobehavioral Genetics, UCLA Neuropsychiatric Institute, David 
      Geffen School of Medicine at UCLA, Los Angeles, California 90024, USA. 
      ssmalley@mednet.ucla.edu
FAU - Loo, Sandra K
AU  - Loo SK
FAU - Yang, May H
AU  - Yang MH
FAU - Cantor, Rita M
AU  - Cantor RM
LA  - eng
GR  - MH58277/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
SB  - IM
EIN - Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136(1):107
MH  - Attention Deficit Disorder with Hyperactivity/genetics
MH  - Autistic Disorder/genetics
MH  - Brain/anatomy & histology/*physiology
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Chromosomes, Human, Pair 16/genetics
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Chromosomes, Human, Pair 2/genetics
MH  - Chromosomes, Human, Pair 5/genetics
MH  - Chromosomes, Human, Pair 7/genetics
MH  - Chromosomes, Human, Pair 9/genetics
MH  - Dyslexia/genetics
MH  - Functional Laterality/physiology
MH  - Genetic Linkage
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genome, Human
MH  - Humans
MH  - *Mental Health
MH  - Siblings
EDAT- 2005/04/05 09:00
MHDA- 2005/06/01 09:00
CRDT- 2005/04/05 09:00
PHST- 2005/04/05 09:00 [pubmed]
PHST- 2005/06/01 09:00 [medline]
PHST- 2005/04/05 09:00 [entrez]
AID - 10.1002/ajmg.b.30141 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):79-84. doi: 
      10.1002/ajmg.b.30141.