PMID- 15807892
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1477-9560 (Print)
IS  - 1477-9560 (Electronic)
IS  - 1477-9560 (Linking)
VI  - 3
IP  - 1
DP  - 2005 Apr 4
TI  - Rates of clinically apparent heparin-induced thrombocytopenia for unfractionated 
      heparin vs. low molecular weight heparin in non-surgical patients are low and 
      similar.
PG  - 4
AB  - With the growing use of low-molecular-weight heparins (LMWH) for the treatment 
      and prevention of venous thromboembolism (VTE), it is important to provide an 
      evidence-based comparison with unfractionated heparin (UFH) concerning rates of 
      heparin-induced thrombocytopenia (HIT). Such comparisons are essential in 
      clinical decision-making and cost-modeling. In this paper we review data 
      regarding non-surgical (medical) patients. We conclude that the lack of uniform 
      evaluation and standardized testing for HIT in the current literature precludes 
      making a reliable estimate of the relative risk of HIT in UFH vs. LMWH in either 
      the treatment or prevention of VTE in non-surgical patients. However, current 
      data suggest that the risk of thrombocytopenia and HIT is low and similar for 
      non-surgical patients who receive either LMWH or UFH.
FAU - Locke, Charles Fs
AU  - Locke CF
AD  - Johns Hopkins Community Physicians Department of Internal Medicine 2360 W, Joppa 
      Rd,, Suite 306 Lutherville, MD 21093 USA. clocke@jhmi.edu.
FAU - Dooley, John
AU  - Dooley J
FAU - Gerber, Jonathan
AU  - Gerber J
LA  - eng
PT  - Journal Article
DEP - 20050404
PL  - England
TA  - Thromb J
JT  - Thrombosis journal
JID - 101170542
PMC - PMC1087886
EDAT- 2005/04/06 09:00
MHDA- 2005/04/06 09:01
PMCR- 2005/04/04
CRDT- 2005/04/06 09:00
PHST- 2004/09/29 00:00 [received]
PHST- 2005/04/04 00:00 [accepted]
PHST- 2005/04/06 09:00 [pubmed]
PHST- 2005/04/06 09:01 [medline]
PHST- 2005/04/06 09:00 [entrez]
PHST- 2005/04/04 00:00 [pmc-release]
AID - 1477-9560-3-4 [pii]
AID - 10.1186/1477-9560-3-4 [doi]
PST - epublish
SO  - Thromb J. 2005 Apr 4;3(1):4. doi: 10.1186/1477-9560-3-4.