PMID- 15810078
OWN - NLM
STAT- MEDLINE
DCOM- 20050518
LR  - 20240511
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 11
IP  - 14
DP  - 2005 Apr 14
TI  - Effects of total glucosides of peony on immunological hepatic fibrosis in rats.
PG  - 2124-9
AB  - AIM: To study the effects of total glucosides of peony (TGP) on immunological 
      hepatic fibrosis induced by human albumin in rats. METHODS: Sixty adult male 
      Sprague-Dawley rats were randomly divided into: Normal group, model group, TGP 
      (60 and 120 mg/kg) treatment groups and colchicines (0.1 mg/kg) treatment group. 
      On the day before the rats were killed, those in TGP or colchicine groups 
      received TGP or colchicine as above from the first day of tail vein injection of 
      human albumin. The rats in normal and model groups were only administered with 
      the same volume of vehicle. At the end of the 16th wk, rats in each group were 
      killed. Blood and tissue specimens were taken. Levels of alanine aminotransferase 
      (ALT), aspartate aminotransferase (AST), nitric oxide (NO), content of 
      malondialdehyde (MDA), activity of superoxide dismutase (SOD) and glutathione 
      peroxidase (GSH-px), were measured by biochemical methods. Serum procollagen type 
      III (PC III) and laminin (LN) were determined by radioimmunoassay. Liver collagen 
      level was determined by measuring hydroxyproline content in fresh liver samples. 
      Hepatic tissue sections were stained with hematoxylin-eosin and examined under a 
      light microscope. RESULTS: Histological results showed that TGP improved the 
      human albumin-induced alterations in the liver structure, alleviated lobular 
      necrosis and significantly lowered collagen content. The antifibrotic effect of 
      TGP was also confirmed by decreased serum content of LN and PCIII in TGP-treated 
      group. Moreover, the treatment with TGP effectively reduced the hydroxyproline 
      content in liver homogenates. However, the level of ALT and AST increased in 
      fibrotic rat but had no significance compared with normal control, whereas the 
      ratio of A/G decreased without significance. TGP had no effect on level of ALT, 
      AST and the ratio of A/G. Furthermore, TGP treatment significantly blocked the 
      increase in MDA and NO, associated with a partial elevation in liver total 
      antioxidant capacity including SOD and GSH-px. CONCLUSION: TGP has beneficial 
      effects on hepatic fibrosis in rats by inhibition of collagen synthesis and 
      decreasing oxidative stress.
FAU - Wang, Hua
AU  - Wang H
AD  - Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, Anhui 
      Province, China.
FAU - Wei, Wei
AU  - Wei W
FAU - Wang, Ni-Ping
AU  - Wang NP
FAU - Wu, Cheng-Yi
AU  - Wu CY
FAU - Yan, Shang-Xue
AU  - Yan SX
FAU - Yue, Li
AU  - Yue L
FAU - Zhang, Ling-Ling
AU  - Zhang LL
FAU - Xu, Shu-Yun
AU  - Xu SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Collagen Type III)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Glucosides)
RN  - 0 (Laminin)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - RMB44WO89X (Hydroxyproline)
SB  - IM
MH  - Animals
MH  - Collagen Type III/blood
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Glucosides/*pharmacology
MH  - Glutathione Peroxidase/metabolism
MH  - Hydroxyproline/metabolism
MH  - Laminin/blood
MH  - Liver/immunology/metabolism/pathology
MH  - Liver Cirrhosis/*drug therapy/immunology/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Oxidative Stress/drug effects
MH  - *Paeonia
MH  - Rats
MH  - Superoxide Dismutase/metabolism
PMC - PMC4305781
EDAT- 2005/04/06 09:00
MHDA- 2005/05/19 09:00
PMCR- 2005/04/14
CRDT- 2005/04/06 09:00
PHST- 2005/04/06 09:00 [pubmed]
PHST- 2005/05/19 09:00 [medline]
PHST- 2005/04/06 09:00 [entrez]
PHST- 2005/04/14 00:00 [pmc-release]
AID - 10.3748/wjg.v11.i14.2124 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2005 Apr 14;11(14):2124-9. doi: 10.3748/wjg.v11.i14.2124.