PMID- 15810654
OWN - NLM
STAT- MEDLINE
DCOM- 20050623
LR  - 20191109
IS  - 0334-1763 (Print)
IS  - 0334-1763 (Linking)
VI  - 16
IP  - 1
DP  - 2005
TI  - Targeting the JNK pathway as a therapeutic protective strategy for nervous system 
      diseases.
PG  - 57-67
AB  - The c-Jun N-terminal kinases (JNKs) are members of the family of mitogen 
      activated protein kinases (MAPKs). While the functions of the JNKs under 
      physiological conditions are diverse and not completely understood, there is 
      increasing evidence that JNKs are potent effectors of apoptosis in both the brain 
      and the mammalian inner ear following a variety of injuries. The activation of 
      the inducible transcription factor c-Jun by N-terminal phosphorylation is a 
      central event in JNK-mediated neural and inner ear hair cell death. A cell 
      permeable peptide designed specifically to inhibit JNK signaling has proven 
      successful in in vivo models of both neuronal degeneration following cerebral 
      ischemia and auditory hair cell degeneration following exposure to either 
      acoustic trauma or a toxic level of an aminoglycoside antibiotic. Here we discuss 
      the evidence supporting the application of JNK inhibitors to prevent cellular 
      degeneration in several central nervous system (CNS) and peripheral nervous 
      system (PNS) diseases with an emphasis on traumatic ischemic damage to the CNS 
      and acquired deafness in the PNS receptors.
FAU - Bonny, Christophe
AU  - Bonny C
AD  - Universite de Lausanne, Lausanne, Switzerland.
FAU - Borsello, Tiziana
AU  - Borsello T
FAU - Zine, Azel
AU  - Zine A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Rev Neurosci
JT  - Reviews in the neurosciences
JID - 8711016
RN  - 0 (Neuroprotective Agents)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/drug therapy/enzymology/physiopathology
MH  - Deafness/drug therapy/enzymology/physiopathology
MH  - Hair Cells, Auditory/drug effects/enzymology/physiopathology
MH  - Humans
MH  - JNK Mitogen-Activated Protein Kinases/drug effects/*metabolism
MH  - Nerve Degeneration/*drug therapy/*enzymology/prevention & control
MH  - Nervous System Diseases/*drug therapy/*enzymology/physiopathology
MH  - Neuroprotective Agents/chemistry/*pharmacology
MH  - Neurotoxicity Syndromes/drug therapy/enzymology/physiopathology
MH  - Signal Transduction/drug effects/physiology
RF  - 59
EDAT- 2005/04/07 09:00
MHDA- 2005/06/24 09:00
CRDT- 2005/04/07 09:00
PHST- 2005/04/07 09:00 [pubmed]
PHST- 2005/06/24 09:00 [medline]
PHST- 2005/04/07 09:00 [entrez]
AID - 10.1515/revneuro.2005.16.1.57 [doi]
PST - ppublish
SO  - Rev Neurosci. 2005;16(1):57-67. doi: 10.1515/revneuro.2005.16.1.57.