PMID- 15811705
OWN - NLM
STAT- MEDLINE
DCOM- 20050721
LR  - 20170922
IS  - 0378-5955 (Print)
IS  - 0378-5955 (Linking)
VI  - 202
IP  - 1-2
DP  - 2005 Apr
TI  - Divergent response properties of layer-V neurons in rat primary auditory cortex.
PG  - 129-40
AB  - Layer-V pyramidal cells comprise a major output of primary auditory cortex (A1). 
      At least two cell types displaying different morphology, projections and in vitro 
      physiology have been previously identified in layer-V. The focus of the present 
      study was to characterize extracellular receptive field properties of layer-V 
      neurons to determine whether a similar breakdown of responses can be found in 
      vivo. Recordings from 105 layer-V neurons revealed two predominant receptive 
      field types. Thirty-two percent displayed strong excitatory V/U-shaped receptive 
      field maps and spiking patterns with shorter stimulus-driven interspike intervals 
      (ISIs), reminiscent of the bursting cells discussed in the in vitro literature. 
      V/U-shaped maps remained relatively unchanged across the three sequential 
      repetitions of the map run on each neuron. Neurons with V/U-shaped maps were also 
      easily depolarized with extracellular current pulse stimulation. In contrast, 47% 
      of the neurons displayed Complex receptive field maps characterized by weak 
      and/or inconsistent excitatory regions and were difficult to depolarize with 
      current pulses. These findings suggest that V/U-shaped receptive fields could 
      correspond to previously described intrinsic bursting (IB) cells with 
      corticotectal projections, and that neurons with Complex receptive fields might 
      represent the regular spiking (RS) cells with their greater inhibitory input and 
      corticocortical/corticostriatal projection pattern.
FAU - Turner, Jeremy G
AU  - Turner JG
AD  - Department of Pharmacology, School of Medicine, Southern Illinois University, 
      Springfield, 62794-9629, USA.
FAU - Hughes, Larry F
AU  - Hughes LF
FAU - Caspary, Donald M
AU  - Caspary DM
LA  - eng
GR  - DC00151/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
SB  - IM
MH  - Acoustic Stimulation
MH  - Action Potentials
MH  - Animals
MH  - Auditory Cortex/cytology/*physiology
MH  - Electric Stimulation
MH  - Pyramidal Cells/*physiology
MH  - Rats
MH  - Rats, Inbred BN
MH  - Reaction Time
EDAT- 2005/04/07 09:00
MHDA- 2005/07/22 09:00
CRDT- 2005/04/07 09:00
PHST- 2005/04/07 09:00 [pubmed]
PHST- 2005/07/22 09:00 [medline]
PHST- 2005/04/07 09:00 [entrez]
AID - S0378-5955(04)00315-6 [pii]
AID - 10.1016/j.heares.2004.09.011 [doi]
PST - ppublish
SO  - Hear Res. 2005 Apr;202(1-2):129-40. doi: 10.1016/j.heares.2004.09.011.