PMID- 15812533
OWN - NLM
STAT- MEDLINE
DCOM- 20050830
LR  - 20181201
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 35 Suppl 1
DP  - 2005 Mar
TI  - Immunotherapy in allogeneic hematopoietic stem cell transplantation--not just a 
      case for effector cells.
PG  - S59-64
AB  - The concept that in allogeneic hematopoietic stem cell transplantation (alloHSCT) 
      the immune system plays a prominent role in the control of leukemic disease is 
      supported by the clinical observation that immunological effector mechanisms 
      contribute to the elimination of leukemic blasts. The failure to induce prolonged 
      remission after alloHSCT has led to resurgent interest in complementing concepts 
      of immune modulation to improve the antileukemic reponse. While the general focus 
      has been placed on manipulation of cytotoxic effector cell populations, we will 
      explore the dual role of leukemia cells as both antigen-presenting and target 
      cells and describe various vaccination strategies to facilitate a protective 
      antileukemic immune response in this setting. In addition, we will introduce 
      mesenchymal stem cells (MSC) as another cell population recently recognized for 
      their immunomodulatory properties. The potential benefits and hazards of 
      MSC-cotransplantation in alloHSCT with regard to the graft versus leukemia (GvL) 
      and the graft versus host (GvH) response will be discussed.
FAU - Troeger, A
AU  - Troeger A
AD  - Clinic for Pediatric Oncology, Hematology and Immunology, University Clinic 
      Dusseldorf, Germany.
FAU - Meisel, R
AU  - Meisel R
FAU - Moritz, T
AU  - Moritz T
FAU - Dilloo, D
AU  - Dilloo D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Animals
MH  - Dendritic Cells/immunology/transplantation
MH  - Graft vs Host Disease/immunology/prevention & control
MH  - Graft vs Leukemia Effect/immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *Immunotherapy, Adoptive/methods
MH  - Leukemia/immunology/*therapy
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/immunology
MH  - Transplantation, Autologous
MH  - Transplantation, Homologous
RF  - 70
EDAT- 2005/04/07 09:00
MHDA- 2005/09/01 09:00
CRDT- 2005/04/07 09:00
PHST- 2005/04/07 09:00 [pubmed]
PHST- 2005/09/01 09:00 [medline]
PHST- 2005/04/07 09:00 [entrez]
AID - 1704849 [pii]
AID - 10.1038/sj.bmt.1704849 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2005 Mar;35 Suppl 1:S59-64. doi: 10.1038/sj.bmt.1704849.