PMID- 15813289
OWN - NLM
STAT- MEDLINE
DCOM- 20050628
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 26
IP  - 1
DP  - 2005 Jan-Feb
TI  - Grape anaphylaxis: a study of 11 adult onset cases.
PG  - 53-8
AB  - Reports of immunoglobulin E (IgE)-mediated allergic reactions to grapes and wine 
      are limited in the literature. Nevertheless, grapes are widely grown and consumed 
      in Mediterranean countries. The object of this prospective study was to present 
      clinical features, in vivo and in vitro allergy testing, and human leukocyte 
      antigen (HLA) serotyping in patients with recurring reactions to grapes and grape 
      products. Eleven unrelated Greek patients, six men and five women (aged 16-44 
      years; mean, 26.9 years) were enrolled based on a documented history of 
      IgE-mediated reactions to grapes, wine, or other grape products. Their evaluation 
      included full history, reaction severity, clinical examination, skin-prick tests 
      with food allergens and molds, serum IgE, specific IgEs to the same allergen 
      battery, and HLA typing. Patients reported 35 grape-induced anaphylaxis episodes 
      ranging from moderate (more than one system involved but not prominent 
      respiratory or cardiovascular symptoms; 45.5%) to severe (serious respiratory 
      obstruction and/or hypotension and loss of consciousness; 54.5%). A causative 
      agent was identified: wine, 10/35 (28.6%); red grapes, 9/35 (25.7%); stuffed vine 
      leaves, 8/35 (22.9%); raisins, 3/35 (8.6%); white grapes, 2/35 (5.7%); wine 
      vinegar, 2/35 (5. 7%); and grape juice, 1/35 (2.9%). Other foods that induced 
      anaphylaxis were apples (54.5%), cherries (18.6%), peaches (18.6%), and bananas 
      (9.3%). Specific IgE values were in accordance with skin-prick tests reactivity. 
      Concerning HLA typing, 9/11 possessed HLA-DR11(5) and -DQ7(3) and the remaining 
      two possessed HLA-DR17(3) and -DQ2 antigens. Grapes, wine and other grape 
      products might cause serious allergic reactions in sensitized individuals. The 
      cosensitization and reaction incidence to other fruit allergens could be a basis 
      for further investigation of panallergens of fruits. HLA class II antigens may 
      contribute in genetic predisposition to these allergic reactions.
FAU - Kalogeromitros, Dimitrios C
AU  - Kalogeromitros DC
AD  - Department of Allergy, University of Athens, Andreas Sygros Hospital, Athens, 
      Greece.
FAU - Makris, Michael P
AU  - Makris MP
FAU - Gregoriou, Stamatios G
AU  - Gregoriou SG
FAU - Mousatou, Vassiliki G
AU  - Mousatou VG
FAU - Lyris, Nikolaos G
AU  - Lyris NG
FAU - Tarassi, Katerina E
AU  - Tarassi KE
FAU - Papasteriades, Chryssa A
AU  - Papasteriades CA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anaphylaxis/*blood
MH  - Antibodies/blood
MH  - Female
MH  - Food Hypersensitivity/blood
MH  - HLA Antigens/*blood/classification
MH  - Histocompatibility Testing
MH  - Humans
MH  - Hypersensitivity, Immediate/*blood
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Skin Tests
MH  - Vitis/*immunology
EDAT- 2005/04/09 09:00
MHDA- 2005/06/29 09:00
CRDT- 2005/04/09 09:00
PHST- 2005/04/09 09:00 [pubmed]
PHST- 2005/06/29 09:00 [medline]
PHST- 2005/04/09 09:00 [entrez]
PST - ppublish
SO  - Allergy Asthma Proc. 2005 Jan-Feb;26(1):53-8.