PMID- 15814550
OWN - NLM
STAT- MEDLINE
DCOM- 20050901
LR  - 20061115
IS  - 0931-0509 (Print)
IS  - 0931-0509 (Linking)
VI  - 20 Suppl 2
DP  - 2005 May
TI  - Impact of HLA matching on the outcome of simultaneous pancreas-kidney 
      transplantation.
PG  - ii48-53, ii62
AB  - BACKGROUND: Simultaneous pancreas-kidney (SPK) transplantation has become the 
      therapy of choice for type 1 diabetic patients with end-stage renal disease. The 
      current analysis examined the impact of human leukocyte antigen (HLA) matching on 
      graft outcome following SPK transplantation. The study population was obtained 
      from patients enrolled in the Euro-SPK 001 study. METHODS: The effect of HLA 
      matching on graft function and survival was assessed in 180 SPK recipients in 
      whom complete donor-recipient HLA data were available. A group of 45 patients 
      with 0-3 HLA mismatches (MM) was compared with a group of 135 patients with 4-6 
      MM. RESULTS: There were no differences in 3-year kidney, pancreas or patient 
      survival between the 0-3 and 4-6 MM groups. Biological parameters of kidney and 
      pancreas graft function were similar in both groups. Significantly more patients 
      with 0-3 MM (66%) were rejection-free at 3 years than was the case among those 
      with 4-6 MM (41%; P = 0.003). The relative risk of acute rejection was 2.6 times 
      higher among patients with 4-6 MM than among those with 0-3 MM. CONCLUSIONS: 
      There was no evidence that HLA matching was associated with improved kidney or 
      pancreas survival. However, a higher rate of acute rejection was observed with 
      poor HLA match, which may impact long-term survival.
FAU - Berney, Thierry
AU  - Berney T
AD  - Division of Visceral and Transplantation Surgery, Geneva University Hospitals, 
      Switzerland.
FAU - Malaise, Jacques
AU  - Malaise J
FAU - Morel, Philippe
AU  - Morel P
FAU - Toso, Christian
AU  - Toso C
FAU - Demuylder-Mischler, Sandrine
AU  - Demuylder-Mischler S
FAU - Majno, Pietro
AU  - Majno P
FAU - Buhler, Leo H
AU  - Buhler LH
FAU - Mentha, Gilles
AU  - Mentha G
CN  - Euro-SPK Study Group
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Diabetes Mellitus, Type 1/complications/surgery
MH  - Diabetic Nephropathies/complications/surgery
MH  - Europe/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/immunology/mortality/prevention & control
MH  - Graft Survival/*immunology
MH  - HLA-A Antigens/*immunology
MH  - HLA-B Antigens/*immunology
MH  - HLA-DR Antigens/*immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Israel/epidemiology
MH  - Kidney Failure, Chronic/etiology/surgery
MH  - Kidney Transplantation/*immunology/mortality
MH  - Male
MH  - Pancreas Transplantation/*immunology/mortality
MH  - Prospective Studies
MH  - Tissue Donors
EDAT- 2005/04/09 09:00
MHDA- 2005/09/02 09:00
CRDT- 2005/04/09 09:00
PHST- 2005/04/09 09:00 [pubmed]
PHST- 2005/09/02 09:00 [medline]
PHST- 2005/04/09 09:00 [entrez]
AID - 20/suppl_2/ii48 [pii]
AID - 10.1093/ndt/gfh1082 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2005 May;20 Suppl 2:ii48-53, ii62. doi: 
      10.1093/ndt/gfh1082.