PMID- 15815044 OWN - NLM STAT- MEDLINE DCOM- 20050614 LR - 20181113 IS - 0095-1137 (Print) IS - 1098-660X (Electronic) IS - 0095-1137 (Linking) VI - 43 IP - 4 DP - 2005 Apr TI - Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child. PG - 2002-3 AB - We report a long-lasting (8-month) reactivation of human herpesvirus 6 (HHV-6) infection in child who had undergone cord blood stem cell transplantation. The reactivation was characterized by high viral loads and by immediate-early mRNA positivity. HHV-6 infection was associated with a deep depletion of CD3, while the CD4/CD8 ratio remained substantially unchanged. FAU - Comar, Manola AU - Comar M AD - Department of Public Medicine Sciences, University of Trieste, Trieste, Italy. FAU - D'Agaro, Pierlanfranco AU - D'Agaro P FAU - Horejsh, Douglas AU - Horejsh D FAU - Galvan, Monica AU - Galvan M FAU - Fiorentini, Simona AU - Fiorentini S FAU - Andolina, Marino AU - Andolina M FAU - Caruso, Arnaldo AU - Caruso A FAU - Di Luca, Dario AU - Di Luca D FAU - Campello, Cesare AU - Campello C LA - eng PT - Case Reports PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Clin Microbiol JT - Journal of clinical microbiology JID - 7505564 RN - 0 (CD3 Complex) SB - IM MH - CD3 Complex/*metabolism MH - CD4-CD8 Ratio MH - Child MH - Cord Blood Stem Cell Transplantation/*adverse effects MH - Herpesvirus 6, Human/*physiology MH - Humans MH - Immunologic Deficiency Syndromes/*etiology MH - Male MH - Roseolovirus Infections/*etiology/virology MH - T-Lymphocytes/*cytology MH - Virus Activation PMC - PMC1081381 EDAT- 2005/04/09 09:00 MHDA- 2005/06/15 09:00 PMCR- 2005/04/01 CRDT- 2005/04/09 09:00 PHST- 2005/04/09 09:00 [pubmed] PHST- 2005/06/15 09:00 [medline] PHST- 2005/04/09 09:00 [entrez] PHST- 2005/04/01 00:00 [pmc-release] AID - 43/4/2002 [pii] AID - 1793-04 [pii] AID - 10.1128/JCM.43.4.2002-2003.2005 [doi] PST - ppublish SO - J Clin Microbiol. 2005 Apr;43(4):2002-3. doi: 10.1128/JCM.43.4.2002-2003.2005.