PMID- 15817207
OWN - NLM
STAT- MEDLINE
DCOM- 20050607
LR  - 20220317
IS  - 0304-4017 (Print)
IS  - 0304-4017 (Linking)
VI  - 129
IP  - 1-2
DP  - 2005 Apr 20
TI  - The effect of free and polyethylene glycol-liposome-entrapped albendazole on 
      larval mobility and number in Toxocara canis infected mice.
PG  - 83-7
AB  - As part of our exploratory drug research on the larva migrans that causes 
      roundworm in dogs and cats, this study was carried out to clarify the effect of 
      free and liposome-entrapped (LE) albendazole in Toxocara canis infected mice. In 
      infected mice, evaluation of mobility and number of larva were examined in detail 
      in the brain, skeletal muscle and liver. Larva mobility was evaluated by using 
      the relative mobility (RM) value. Albendazole was LE as one of the drug delivery 
      systems (DDSs). Polyethylene glycol (PEG) was added to the liposome in order to 
      avoid evoking a response by the reticuloendothelial system (RES). By using the 
      albendazole PEG-LE delivery system, it was possible to target the larvae in the 
      mouse brain and liver resulting in a decrease in the number of larvae. In the 
      skeletal muscle of the infected mice, the intraperitoneal dosages of PEG-LE 
      albendazole did not cause a complete decrease in the number of larvae, even 
      though free albendazole did cause the number to decrease. Therefore, it is 
      necessary to take into consideration the migrating stage of the larvae before the 
      initiation of any drug administration.
FAU - Horiuchi, Akiko
AU  - Horiuchi A
AD  - Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University, 
      2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
FAU - Satou, Tadaaki
AU  - Satou T
FAU - Akao, Nobuaki
AU  - Akao N
FAU - Koike, Kazuo
AU  - Koike K
FAU - Fujita, Koichiro
AU  - Fujita K
FAU - Nikaido, Tamotsu
AU  - Nikaido T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Parasitol
JT  - Veterinary parasitology
JID - 7602745
RN  - 0 (Anthelmintics)
RN  - 0 (Liposomes)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - F4216019LN (Albendazole)
SB  - IM
MH  - Albendazole/administration & dosage/pharmacology/*therapeutic use
MH  - Animals
MH  - Anthelmintics/administration & dosage/pharmacology/*therapeutic use
MH  - Brain/parasitology
MH  - Disease Models, Animal
MH  - Injections, Intraperitoneal/veterinary
MH  - Larva
MH  - Liposomes
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Movement
MH  - Polyethylene Glycols
MH  - Toxocara canis/drug effects/*growth & development
MH  - Toxocariasis/*drug therapy
MH  - Treatment Outcome
EDAT- 2005/04/09 09:00
MHDA- 2005/06/09 09:00
CRDT- 2005/04/09 09:00
PHST- 2004/12/04 00:00 [accepted]
PHST- 2005/04/09 09:00 [pubmed]
PHST- 2005/06/09 09:00 [medline]
PHST- 2005/04/09 09:00 [entrez]
AID - S0304-4017(05)00006-3 [pii]
AID - 10.1016/j.vetpar.2004.12.017 [doi]
PST - ppublish
SO  - Vet Parasitol. 2005 Apr 20;129(1-2):83-7. doi: 10.1016/j.vetpar.2004.12.017.