PMID- 15820036
OWN - NLM
STAT- MEDLINE
DCOM- 20050711
LR  - 20190917
IS  - 1472-6483 (Print)
IS  - 1472-6483 (Linking)
VI  - 10
IP  - 3
DP  - 2005 Mar
TI  - Ethical consideration of intentioned preimplantation genetic diagnosis to enable 
      future tissue transplantation.
PG  - 320-4
AB  - Recently, a case was presented where a couple with one normal child requested 
      preimplantation genetic diagnosis (PGD) with human leukocyte antigen (HLA) typing 
      in order to conceive children who could serve as mutual donors for future 
      transplantations if needed. While PGD for medical reasons is well defined and 
      accepted, application for non-medical conditions is less obvious and still in 
      debate. The present case calls to further extend the indications for PGD and 
      raises a moral question as to whether to allow such intentioned treatment. 
      Although it seems that all siblings might benefit from the procedure, when 
      weighing the risks benefits and the ethical issues included in performing 
      intentioned PGD, it seems that the procedure harbours risks and ethical issues 
      that outweigh the benefit it offers. Therefore, it is time to constrain the 
      slippery slope and state that intentioned PGD for conceiving children who might 
      serve as siblings for mutual tissue donations should be declined.
FAU - Simon, Alex
AU  - Simon A
AD  - Department of Obstetrics and Gynecology, Hadassah University Hospital, Ein Kerem, 
      PO Box 12000, Jerusalem 91120, Israel. asimon@md.huji.ac.il
FAU - Schenker, Joseph G
AU  - Schenker JG
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Directed Tissue Donation/*ethics
MH  - Embryo, Mammalian
MH  - Female
MH  - Fertilization in Vitro/adverse effects
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Morals
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*ethics
MH  - Risk Factors
MH  - Tissue Donors/*ethics
EDAT- 2005/04/12 09:00
MHDA- 2005/07/12 09:00
CRDT- 2005/04/12 09:00
PHST- 2005/04/12 09:00 [pubmed]
PHST- 2005/07/12 09:00 [medline]
PHST- 2005/04/12 09:00 [entrez]
AID - S1472-6483(10)61790-7 [pii]
AID - 10.1016/s1472-6483(10)61790-7 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2005 Mar;10(3):320-4. doi: 10.1016/s1472-6483(10)61790-7.