PMID- 15820412
OWN - NLM
STAT- MEDLINE
DCOM- 20050608
LR  - 20220311
IS  - 0924-977X (Print)
IS  - 0924-977X (Linking)
VI  - 15
IP  - 3
DP  - 2005 May
TI  - Urinary excretion of biopyrrins, oxidative metabolites of bilirubin, increases in 
      patients with psychiatric disorders.
PG  - 249-52
AB  - Several authors have suggested that psychological stress induces the production 
      of reactive oxygen species (ROS). Several studies have supported the idea that 
      bilirubin exerts antioxidative effects in vivo, and it was reported psychological 
      stress provokes bilirubin oxidation in vivo [Yamaguchi T., Shioji I., Sugimoto 
      A., Yamaoka M., 2002. Psychological stress increases bilirubin metabolites in 
      human urine. Biochem. and Biophys. Res. Commun. 293, 517-520]. We investigated 
      whether the concentration of bilirubin oxidative metabolites (biopyrrins) is 
      increased in urine from patients with psychiatric disorders. The concentration of 
      biopyrrins in urine of 25 patients with psychiatric disorders (schizophrenia, 15; 
      depression, 10) was compared with 96 healthy volunteers. The concentrations of 
      biopyrrins, as measured by enzyme-linked immunosorbent assay, were normalized to 
      the urinary concentration of creatinine. The concentration of biopyrrins in 
      patients with psychiatric disorders (schizophrenia and depression) was 
      significantly higher than that of healthy volunteers. In schizophrenia, 
      biopyrrins levels correlated with scores of the Brief Psychiatric Rating Scale 
      (BPRS), and in depression, biopyrrins levels correlated with scores of the 
      Hamilton Depression Rating Scale (HAM-D). These finding suggest that psychotic 
      states are associated with an increase in the oxidative metabolites of bilirubin 
      in human urine.
FAU - Miyaoka, Tsuyoshi
AU  - Miyaoka T
AD  - Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, 
      Izumo 693-8501, Japan. miyanyan@med.shimane-u.ac.jp
FAU - Yasukawa, Rei
AU  - Yasukawa R
FAU - Yasuda, Hideaki
AU  - Yasuda H
FAU - Shimizu, Maiko
AU  - Shimizu M
FAU - Mizuno, Soichi
AU  - Mizuno S
FAU - Sukegawa, Tsuruhei
AU  - Sukegawa T
FAU - Inagaki, Takuji
AU  - Inagaki T
FAU - Horiguchi, Jun
AU  - Horiguchi J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050125
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Adult
MH  - Bilirubin/*urine
MH  - Biomarkers/urine
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/*urine
MH  - Oxidation-Reduction
MH  - Oxidative Stress/physiology
MH  - Psychiatric Status Rating Scales
MH  - Reactive Oxygen Species
MH  - Schizophrenia/urine
MH  - Stress, Psychological/psychology/urine
EDAT- 2005/04/12 09:00
MHDA- 2005/06/09 09:00
CRDT- 2005/04/12 09:00
PHST- 2004/07/20 00:00 [received]
PHST- 2004/11/17 00:00 [revised]
PHST- 2004/11/17 00:00 [accepted]
PHST- 2005/04/12 09:00 [pubmed]
PHST- 2005/06/09 09:00 [medline]
PHST- 2005/04/12 09:00 [entrez]
AID - S0924-977X(04)00194-4 [pii]
AID - 10.1016/j.euroneuro.2004.11.002 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2005 May;15(3):249-52. doi: 
      10.1016/j.euroneuro.2004.11.002. Epub 2005 Jan 25.