PMID- 15821011
OWN - NLM
STAT- MEDLINE
DCOM- 20060522
LR  - 20191210
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 27
IP  - 6
DP  - 2006 Mar
TI  - Prognostic significance of serum cholesterol levels in patients with idiopathic 
      dilated cardiomyopathy.
PG  - 691-9
AB  - AIMS: Previous studies indicate that low cholesterol levels are associated with 
      adverse prognosis in heart failure patients, because elevated lipoprotein levels 
      may negate bacterial endotoxin load induced by gastrointestinal congestion. 
      METHODS AND RESULTS: We examined the prognostic significance of lipid levels in a 
      cohort of 422 patients with idiopathic dilated cardiomyopathy (iDCM) [50+/-12 
      years, 342 males, 80 females, left ventricular ejection fraction (LV-EF): 
      31.6+/-10.6%]. During 42 months of follow-up, 86 patients (20.3%) died or 
      received a heart transplant. In univariate Cox regression analysis, reduced 
      LV-EF, high New York Heart Association (NYHA) class, and increased LV 
      end-diastolic diameter (LVEDD) were strong risk factors associated with that 
      endpoint, whereas decreased total cholesterol, HDL-cholesterol, and apoprotein I 
      levels were identified as weak risk predictors. After step-wise multivariable 
      analysis, only LVEDD, NYHA class, and LV-EF emerged as parameters independently 
      contributing to the model predicting risk for death or heart transplantation 
      (P<0.05). Cholesterol levels were positively associated with LV-EF and negatively 
      associated with LVEDD (P<0.05). Circulating sCD14 levels, a marker of endotoxin 
      exposure, were related to cholesterol levels (P<0.05) and LV-EF (P<0.05). 
      CONCLUSION: Decreased cholesterol levels do not independently predict adverse 
      prognosis in patients with iDCM. Our findings indicate that low cholesterol 
      levels are dependent on the severity of cardiac disease.
FAU - Christ, Michael
AU  - Christ M
AD  - Klinik fur Innere Medizin, Kardiologie und Intensivmedizin, Philipps University 
      Marburg, Baldingerstrasse, D-35033 Marburg, Germany. christ_michael@yahoo.de
FAU - Klima, Theresia
AU  - Klima T
FAU - Grimm, Wolfram
AU  - Grimm W
FAU - Mueller, Hans-Helge
AU  - Mueller HH
FAU - Maisch, Bernhard
AU  - Maisch B
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20050408
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
CIN - Eur Heart J. 2005 Sep;26(18):1931; author reply 1931-2. PMID: 16014641
CIN - Eur Heart J. 2006 Mar;27(6):641-3. PMID: 16490737
MH  - Adult
MH  - Cardiomyopathy, Dilated/*blood
MH  - Cholesterol/*blood
MH  - Epidemiologic Methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Severity of Illness Index
EDAT- 2005/04/12 09:00
MHDA- 2006/05/23 09:00
CRDT- 2005/04/12 09:00
PHST- 2005/04/12 09:00 [pubmed]
PHST- 2006/05/23 09:00 [medline]
PHST- 2005/04/12 09:00 [entrez]
AID - ehi195 [pii]
AID - 10.1093/eurheartj/ehi195 [doi]
PST - ppublish
SO  - Eur Heart J. 2006 Mar;27(6):691-9. doi: 10.1093/eurheartj/ehi195. Epub 2005 Apr 
      8.