PMID- 15821762
OWN - NLM
STAT- MEDLINE
DCOM- 20050819
LR  - 20050518
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 35
IP  - 11
DP  - 2005 Jun
TI  - The implication of follicular lymphoma patients receiving allogeneic stem cell 
      transplantation from donors carrying t(14;18)-positive cells.
PG  - 1049-54
AB  - We performed real-time quantitative polymerase chain reaction (RQ-PCR) in 
      peripheral blood (PB) and/or bone marrow (BM) samples collected pre- and post 
      transplant from 23 recipient-donor pairs receiving allogeneic stem cell 
      transplantation (allo-SCT) for follicular lymphoma (FL). Of 23 donors, 11 had a 
      PB and/or BM sample positive for t(14;18) (BCL2/IGH fusion) at low levels (<one 
      t(14;18) cell in 10K total cells). Recipients from donors with (n=11) and those 
      without (n=12) detectable t(14:18) cells were similar in age, sex, and disease 
      status pretransplant. No differences in the incidence of 
      graft-versus-host-disease (GVHD), delayed engraftment, relapse rate, disease-free 
      survival and overall survival were identified between the groups. Two recipients 
      without detectable t(14;18) cells pre-transplant showed detectable t(14;18) cells 
      at 2 and 11 years after receiving grafts from donors with t(14:18) cells. Neither 
      patient developed FL 1.5 and 2 years after the emergence of t(14;18) cells. 
      Although the sample size is relatively small, our findings suggest that 
      individuals carrying t(14;18) cells may not be excluded as donors given the lack 
      of an association of t(14;18) detected in donors with adverse clinical outcome. 
      It may be necessary to screen for the donor's t(14;18) status before using 
      t(14;18) for monitoring minimal residual disease by RQ-PCR to exclude the 
      possibility of confounding donor's t(14;18) clone.
FAU - McGregor, D K
AU  - McGregor DK
AD  - Department of Pathology, The Methodist Hospital, Baylor College of Medicine, 6565 
      Fannin Street, Houston, TX 77030, USA.
FAU - Keever-Taylor, C A
AU  - Keever-Taylor CA
FAU - Bredeson, C
AU  - Bredeson C
FAU - Schur, B
AU  - Schur B
FAU - Vesole, D H
AU  - Vesole DH
FAU - Logan, B
AU  - Logan B
FAU - Chang, C-C
AU  - Chang CC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Adult
MH  - Bone Marrow Cells/cytology
MH  - Chromosomes, Human, Pair 14/*ultrastructure
MH  - Chromosomes, Human, Pair 18/*ultrastructure
MH  - Disease-Free Survival
MH  - Female
MH  - Graft vs Host Disease
MH  - Humans
MH  - Lymphoma, Follicular/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Retrospective Studies
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Stem Cell Transplantation/*methods
MH  - Time Factors
MH  - Tissue Donors
MH  - *Translocation, Genetic
MH  - Transplantation, Homologous/methods
MH  - Treatment Outcome
EDAT- 2005/04/12 09:00
MHDA- 2005/08/20 09:00
CRDT- 2005/04/12 09:00
PHST- 2005/04/12 09:00 [pubmed]
PHST- 2005/08/20 09:00 [medline]
PHST- 2005/04/12 09:00 [entrez]
AID - 1704969 [pii]
AID - 10.1038/sj.bmt.1704969 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2005 Jun;35(11):1049-54. doi: 10.1038/sj.bmt.1704969.