PMID- 15824368
OWN - NLM
STAT- MEDLINE
DCOM- 20060210
LR  - 20050412
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 64
IP  - 7
DP  - 2005 Apr 12
TI  - Heparin-induced thrombocytopenia in neurologic patients treated with 
      low-molecular-weight heparin.
PG  - 1285-7
AB  - The authors prospectively studied the risk for immune-mediated heparin-induced 
      thrombocytopenia (HIT) in neurologic patients during administration of 
      low-molecular-weight heparin (LMWH) vs unfractionated heparin (UFH). None of 111 
      neurologic patients receiving LMWH developed HIT, whereas HIT occurred in 2.5% of 
      200 patients treated with UFH (p = 0.17). The rate of heparin-induced antibodies 
      in patients treated with LMWH was lower than in patients treated with UFH (1.8 vs 
      20.5%; p < 0.001).
FAU - Pohl, C
AU  - Pohl C
AD  - Department of Neurology, University Hospital Bonn, Germany.
FAU - Kredteck, A
AU  - Kredteck A
FAU - Bastians, B
AU  - Bastians B
FAU - Hanfland, P
AU  - Hanfland P
FAU - Klockgether, T
AU  - Klockgether T
FAU - Harbrecht, U
AU  - Harbrecht U
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Anticoagulants)
RN  - 0 (Autoantibodies)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/administration & dosage/*adverse effects/immunology
MH  - Autoantibodies/blood/immunology
MH  - Cerebrovascular Disorders/*drug therapy
MH  - Cohort Studies
MH  - Drug Administration Schedule
MH  - Female
MH  - Heparin/administration & dosage/adverse effects/immunology
MH  - Heparin, Low-Molecular-Weight/administration & dosage/*adverse effects/immunology
MH  - Humans
MH  - Iatrogenic Disease/prevention & control
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Thrombocytopenia/*chemically induced/epidemiology/*immunology
EDAT- 2005/04/13 09:00
MHDA- 2006/02/14 09:00
CRDT- 2005/04/13 09:00
PHST- 2005/04/13 09:00 [pubmed]
PHST- 2006/02/14 09:00 [medline]
PHST- 2005/04/13 09:00 [entrez]
AID - 64/7/1285 [pii]
AID - 10.1212/01.WNL.0000156947.45112.16 [doi]
PST - ppublish
SO  - Neurology. 2005 Apr 12;64(7):1285-7. doi: 10.1212/01.WNL.0000156947.45112.16.