PMID- 15824823
OWN - NLM
STAT- MEDLINE
DCOM- 20060105
LR  - 20211203
IS  - 0034-9887 (Print)
IS  - 0034-9887 (Linking)
VI  - 133
IP  - 2
DP  - 2005 Feb
TI  - [Relationship of oncogene C-erbB-2 amplification in breast cancer with 
      pathological parameters and disease free survival].
PG  - 151-7
AB  - BACKGROUND: Proto-oncogene c-erbB-2 is located in chromosome 17 region q21 and 
      codifies a 185 Kd protein, with tyrosine kinase activity. The amplification of 
      this gene is associated with relapse and lower survival in breast cancer. 
      Overexpression of this gene can be detected by immunohistochemistry (IHC). 
      However, fluorescence in situ hybridization (FISH) and chromogenic in situ 
      hybridization (CISH) allow the simultaneous analysis of morphology and 
      overexpression of the gene. AIM: To evaluate the relationship of c-erbB-2 
      oncogene amplification measured by FISH with histological graduation, presence of 
      positive Iymph nodes and evolution of breast cancer. PATIENTS AND METHODS: One 
      hundred and ten tissue samples of invasive ductal or lobulillar breast cancer, 
      positive for c-erbB-2 oncogene by IHC were analysed. The presence of c-erbB-2 
      oncogene amplification was subsequently analyzed by FISH. RESULTS: There was a 
      significant association of c-erbB-2 amplification by FISH with pathological 
      graduation of the tumor, number of regional Iymph nodes involved and disease free 
      survival. CONCLUSIONS: Proto-oncogene c-erbB-2 amplification is a good indicator 
      of bad prognosis in invasive breast cancer.
FAU - Rojas-Atencio, Alicia E
AU  - Rojas-Atencio AE
AD  - Unidad de Genetica Medica, Facultad de Medicina, Universidad del Zulia, 
      Maracaibo, Venezuela. arojasa@cantv.net
FAU - Valbuena, Ivonne
AU  - Valbuena I
FAU - Urdaneta, Karelis
AU  - Urdaneta K
FAU - Soto-Quintana, Marisol
AU  - Soto-Quintana M
FAU - Alvarez-Nava, Francisco
AU  - Alvarez-Nava F
FAU - Gonzalez, Leonardo
AU  - Gonzalez L
FAU - Viloria-Alvarado, Maria E
AU  - Viloria-Alvarado ME
FAU - Quintero-Bellagamba, Rita
AU  - Quintero-Bellagamba R
LA  - spa
PT  - Journal Article
TT  - Relacion entre la amplificacion del oncogen C-erbB-2 y parametros histologicos 
      con sobrevida libre de enfermedad en pacientes con cancer de mama.
DEP - 20050407
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Breast Neoplasms/*genetics/mortality/*pathology
MH  - Carcinoma, Ductal, Breast/genetics/mortality/pathology
MH  - Chile
MH  - Female
MH  - Follow-Up Studies
MH  - *Gene Amplification
MH  - Genes, erbB-2/*genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Neoplasm Invasiveness
MH  - Prognosis
MH  - Proto-Oncogene Mas
EDAT- 2005/04/13 09:00
MHDA- 2006/01/06 09:00
CRDT- 2005/04/13 09:00
PHST- 2005/04/13 09:00 [pubmed]
PHST- 2006/01/06 09:00 [medline]
PHST- 2005/04/13 09:00 [entrez]
AID - S0034-98872005000200001 [pii]
AID - 10.4067/s0034-98872005000200001 [doi]
PST - ppublish
SO  - Rev Med Chil. 2005 Feb;133(2):151-7. doi: 10.4067/s0034-98872005000200001. Epub 
      2005 Apr 7.