PMID- 15828219
OWN - NLM
STAT- MEDLINE
DCOM- 20050527
LR  - 20181201
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 63
IP  - 4
DP  - 2005 Apr
TI  - [PPARs as molecular targets for drug discovery].
PG  - 549-55
AB  - Peroxisome proliferator-activated receptors (PPARs) are ligand-inducible 
      transcription factors. PPARs form the heterodimers with retinoid X receptors 
      (RXRs), and modulate specific gene expressions related to the lipid and 
      carbohydrate metabolism. Since fibrate-type lipid-lowering agents and 
      thiazolidinedione (TZD)-type antidiabetic agents are identified as PPARalpha and 
      gamma agonists, respectively, a number of ligands for PPARs have been developed, 
      including PPAR subtype-selective and dual agonists. Recent report that RXR 
      antagonist exhibited antidiabetic and antiobestic activities in animal model 
      experiments, PPARs partial agonists, antagonists, and RXR antagonists have been 
      also synthesized and their function in vivo are under investigations. In this 
      paper, recent studies on the ligands for the PPAR-RXR heterodimers are reviewed.
FAU - Kagechika, Hiroyuki
AU  - Kagechika H
AD  - School of Biomedical Science, Tokyo Medical and Dental University.
FAU - Miyachi, Hiroyuki
AU  - Miyachi H
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Peroxisome Proliferator-Activated Receptors)
RN  - 0 (Pregnane X Receptor)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Steroid)
SB  - IM
MH  - *Drug Design
MH  - Hypoglycemic Agents/therapeutic use
MH  - Peroxisome Proliferator-Activated Receptors/*agonists/*physiology
MH  - Pregnane X Receptor
MH  - Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors/physiology
MH  - Receptors, Steroid/antagonists & inhibitors/physiology
RF  - 20
EDAT- 2005/04/15 09:00
MHDA- 2005/05/28 09:00
CRDT- 2005/04/15 09:00
PHST- 2005/04/15 09:00 [pubmed]
PHST- 2005/05/28 09:00 [medline]
PHST- 2005/04/15 09:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2005 Apr;63(4):549-55.