PMID- 15829988
OWN - NLM
STAT- MEDLINE
DCOM- 20050907
LR  - 20151119
IS  - 0955-9930 (Print)
IS  - 0955-9930 (Linking)
VI  - 17
IP  - 4
DP  - 2005 Jul-Aug
TI  - PDE-5 inhibitor, Vardenafil, increases circulating progenitor cells in humans.
PG  - 377-80
AB  - Bone marrow-derived endothelial progenitor cells (EPCs) originate from 
      haematopoietic stem cells in bone marrow and migrate into the peripheral 
      circulation to promote endothelial repair and neovascularization. The number of 
      circulating progenitor cells is reduced in patients with cardiovascular risk 
      factor. The aim of our study was to determine the number of these cells in 
      healthy patients and to evaluate the effect of Vardenfil, a phosphodiesterases-5 
      (PDE-5) inhibitor, in the number of circulating EPCs. In our study, we found a 
      significant increase in the number of these cells after the drug administration.
FAU - Foresta, C
AU  - Foresta C
AD  - Department of Histology, Microbiology, and Medical Biotechnologies, Centre for 
      Male Gamete Cryopreservation, University of Padova, Padova, Italy. 
      carlo.foresta@unipd.it
FAU - Lana, A
AU  - Lana A
FAU - Cabrelle, A
AU  - Cabrelle A
FAU - Ferigo, M
AU  - Ferigo M
FAU - Caretta, N
AU  - Caretta N
FAU - Garolla, A
AU  - Garolla A
FAU - Palu, G
AU  - Palu G
FAU - Ferlin, A
AU  - Ferlin A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Int J Impot Res
JT  - International journal of impotence research
JID - 9007383
RN  - 0 (Imidazoles)
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 0 (Piperazines)
RN  - 0 (Sulfones)
RN  - 0 (Triazines)
RN  - 5O8R96XMH7 (Vardenafil Dihydrochloride)
RN  - EC 3.1.4.35 (3',5'-Cyclic-GMP Phosphodiesterases)
RN  - EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 5)
RN  - EC 3.1.4.35 (PDE5A protein, human)
SB  - IM
MH  - 3',5'-Cyclic-GMP Phosphodiesterases/*antagonists & inhibitors
MH  - Adult
MH  - Cyclic Nucleotide Phosphodiesterases, Type 5
MH  - Endothelium, Vascular/cytology
MH  - Flow Cytometry
MH  - *Hematopoietic Stem Cell Mobilization
MH  - Hematopoietic Stem Cells/cytology/*drug effects
MH  - Humans
MH  - Imidazoles/*administration & dosage
MH  - Male
MH  - Phosphodiesterase Inhibitors/*administration & dosage
MH  - Piperazines/*administration & dosage
MH  - Sulfones/administration & dosage
MH  - Triazines/administration & dosage
MH  - Vardenafil Dihydrochloride
EDAT- 2005/04/15 09:00
MHDA- 2005/09/08 09:00
CRDT- 2005/04/15 09:00
PHST- 2005/04/15 09:00 [pubmed]
PHST- 2005/09/08 09:00 [medline]
PHST- 2005/04/15 09:00 [entrez]
AID - 3901325 [pii]
AID - 10.1038/sj.ijir.3901325 [doi]
PST - ppublish
SO  - Int J Impot Res. 2005 Jul-Aug;17(4):377-80. doi: 10.1038/sj.ijir.3901325.