PMID- 15831297
OWN - NLM
STAT- MEDLINE
DCOM- 20050607
LR  - 20171116
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 83 Suppl 1
DP  - 2005 Apr
TI  - Human leukocyte antigen expression by peritoneal macrophages from women with 
      pelvic endometriosis is depressed but coordinated with costimulatory molecule 
      expression.
PG  - 1232-40
AB  - OBJECTIVE: To investigate the macrophage response in endometriosis, we determined 
      expression of human leukocyte antigen (HLA)-ABC, HLA-DR, and their costimulatory 
      molecules by peritoneal fluid (PF) macrophages. DESIGN: Case-control study of 
      immunologic markers. SETTING: University hospital. PATIENT(S): We compared 38 
      Japanese women with endometriosis with 59 control subjects who were given other 
      laparoscopic diagnoses. INTERVENTION(S): Venipuncture and laparoscopic peritoneal 
      fluid collection. MAIN OUTCOME MEASURE(S): Expression of HLA-ABC, HLA-DR, CD54, 
      CD40, CD58, CD80, and CD86 by peripheral blood (PB) monocytes and PF macrophages 
      was quantitated as mean fluorescence intensities by flow cytometry. Expression of 
      each marker on PF macrophages was divided by that on PB monocytes as an index of 
      macrophage activation (macrophage activation ratio). RESULT(S): In women with 
      endometriosis, PF macrophages showed significant positive correlations between 
      expression of HLA-ABC and other costimulatory molecules and also between HLA-DR 
      and their costimulatory molecules. However, expression of HLA-ABC and DR by PF 
      macrophages, and also their activation ratios, were significantly lower than in 
      controls. CONCLUSION(S): Coordination with costimulatory molecules but relatively 
      low expression of HLA-ABC and HLA-DR indicates a positive but limited immune 
      response (antigen presentation) to events in the peritoneal cavity in women with 
      endometriosis. This may induce immune tolerance to implanted or metaplastic 
      endometrial tissue.
FAU - Kusume, Tomoaki
AU  - Kusume T
AD  - Department of Obstetrics and Gynecology, Kochi Medical School, Kohasu, Oko, 
      Nankoku, Kochi 783-8505, Japan. kusumet@pop07.odn.ne.jp
FAU - Maeda, Nagamasa
AU  - Maeda N
FAU - Izumiya, Chiaki
AU  - Izumiya C
FAU - Yamamoto, Yorito
AU  - Yamamoto Y
FAU - Hayashi, Kazutoshi
AU  - Hayashi K
FAU - Oguri, Hiroyoshi
AU  - Oguri H
FAU - Nishimori, Yoshiko
AU  - Nishimori Y
FAU - Fukaya, Takao
AU  - Fukaya T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Antigens, CD)
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Biomarkers)
RN  - 0 (CD40 Antigens)
RN  - 0 (CD58 Antigens)
RN  - 0 (CD86 protein, human)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Membrane Glycoproteins)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adult
MH  - Antigen Presentation/immunology
MH  - Antigens, CD/metabolism
MH  - B7-1 Antigen/metabolism
MH  - B7-2 Antigen
MH  - Biomarkers/*metabolism
MH  - CD40 Antigens/metabolism
MH  - CD58 Antigens/metabolism
MH  - Case-Control Studies
MH  - Endometriosis/*immunology/*metabolism
MH  - Female
MH  - Flow Cytometry
MH  - HLA Antigens/*metabolism
MH  - HLA-A Antigens/metabolism
MH  - HLA-B Antigens/metabolism
MH  - HLA-C Antigens/metabolism
MH  - HLA-DR Antigens/metabolism
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Macrophages, Peritoneal/*metabolism
MH  - Membrane Glycoproteins/metabolism
EDAT- 2005/04/16 09:00
MHDA- 2005/06/09 09:00
CRDT- 2005/04/16 09:00
PHST- 2004/07/02 00:00 [received]
PHST- 2004/11/30 00:00 [revised]
PHST- 2004/11/30 00:00 [accepted]
PHST- 2005/04/16 09:00 [pubmed]
PHST- 2005/06/09 09:00 [medline]
PHST- 2005/04/16 09:00 [entrez]
AID - S0015-0282(04)03249-2 [pii]
AID - 10.1016/j.fertnstert.2004.11.039 [doi]
PST - ppublish
SO  - Fertil Steril. 2005 Apr;83 Suppl 1:1232-40. doi: 
      10.1016/j.fertnstert.2004.11.039.