PMID- 15833381
OWN - NLM
STAT- MEDLINE
DCOM- 20050714
LR  - 20121115
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 43
IP  - 7
DP  - 2005 Jul
TI  - Developmental toxicity of two trimethylbenzene isomers, mesitylene and 
      pseudocumene, in rats following inhalation exposure.
PG  - 1055-63
AB  - The developmental toxicity of two trimethylbenzene isomers, mesitylene 
      (1,3,5-trimethylbenzene) and pseudocumene (1,2,4-trimethylbenzene) was studied in 
      Sprague-Dawley rats following inhalation exposure. Pregnant rats were exposed 
      whole body to vapours of mesitylene (0, 100, 300, 600, and 1200 ppm) or 
      pseudocumene (0, 100, 300, 600, and 900 ppm), 6h/day, on gestational days (GD) 6 
      through 20. Significant decrease in maternal body weight gain and food 
      consumption was observed at concentrations of 300 ppm mesitylene, 600 ppm 
      pseudocumene, or greater. Fetal toxicity, expressed as significant reduction in 
      fetal body weight, occurred at 600 and 1200 ppm mesitylene, and at 600 and 900 
      ppm pseudocumene. There was no evidence of embryolethal or teratogenic effects 
      following inhalation exposure to either of these chemicals. In summary, the 
      no-observed-adverse-effect-level (NOAEL) for maternal toxicity was 100 ppm for 
      mesitylene and 300 ppm for pseudocumene, and the NOAEL for developmental toxicity 
      was 300 ppm for mesitylene and pseudocumene.
FAU - Saillenfait, A M
AU  - Saillenfait AM
AD  - Institut National de Recherche et de Securite, Avenue de Bourgogne, B.P. No. 27, 
      54501 Vandoeuvre, France. anne-marie.saillenfait@inrs.fr
FAU - Gallissot, F
AU  - Gallissot F
FAU - Sabate, J P
AU  - Sabate JP
FAU - Morel, G
AU  - Morel G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Benzene Derivatives)
RN  - 0 (Teratogens)
RN  - 34X0W8052F (pseudocumene)
RN  - 887L18KQ6X (mesitylene)
SB  - IM
MH  - Abnormalities, Drug-Induced/epidemiology/pathology
MH  - Administration, Inhalation
MH  - Animals
MH  - Benzene Derivatives/administration & dosage/*toxicity
MH  - Body Weight/drug effects
MH  - Bone and Bones/abnormalities
MH  - Eating/drug effects
MH  - Female
MH  - Fetal Death/chemically induced
MH  - Fetal Development/*drug effects
MH  - Fetal Resorption/chemically induced
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Teratogens/*toxicity
EDAT- 2005/04/19 09:00
MHDA- 2005/07/15 09:00
CRDT- 2005/04/19 09:00
PHST- 2004/09/29 00:00 [received]
PHST- 2005/02/09 00:00 [revised]
PHST- 2005/02/15 00:00 [accepted]
PHST- 2005/04/19 09:00 [pubmed]
PHST- 2005/07/15 09:00 [medline]
PHST- 2005/04/19 09:00 [entrez]
AID - S0278-6915(05)00072-4 [pii]
AID - 10.1016/j.fct.2005.02.008 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2005 Jul;43(7):1055-63. doi: 10.1016/j.fct.2005.02.008.