PMID- 15834410
OWN - NLM
STAT- MEDLINE
DCOM- 20050516
LR  - 20201222
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 6
IP  - 5
DP  - 2005 May
TI  - Egr-2 and Egr-3 are negative regulators of T cell activation.
PG  - 472-80
AB  - T cell receptor engagement in the absence of proper accessory signals leads to T 
      cell anergy. E3 ligases are involved in maintaining the anergic state. However, 
      the specific molecules responsible for the induction of anergy have yet to be 
      elucidated. Using microarray analysis we have identified here early growth 
      response gene 2 (Egr-2) and Egr-3 as key negative regulators of T cell 
      activation. Overexpression of Egr2 and Egr3 was associated with an increase in 
      the E3 ubiquitin ligase Cbl-b and inhibition of T cell activation. Conversely, T 
      cells from Egr3(-/-) mice had lower expression of Cbl-b and were resistant to in 
      vivo peptide-induced tolerance. These data support the idea that Egr-2 and Egr-3 
      are involved in promoting a T cell receptor-induced negative regulatory genetic 
      program.
FAU - Safford, Meredith
AU  - Safford M
AD  - The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of 
      Medicine, Baltimore, Maryland, USA.
FAU - Collins, Samuel
AU  - Collins S
FAU - Lutz, Michael A
AU  - Lutz MA
FAU - Allen, Amy
AU  - Allen A
FAU - Huang, Ching-Tai
AU  - Huang CT
FAU - Kowalski, Jeanne
AU  - Kowalski J
FAU - Blackford, Amanda
AU  - Blackford A
FAU - Horton, Maureen R
AU  - Horton MR
FAU - Drake, Charles
AU  - Drake C
FAU - Schwartz, Ronald H
AU  - Schwartz RH
FAU - Powell, Jonathan D
AU  - Powell JD
LA  - eng
GR  - R01 CA098109-02/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050417
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Cblb protein, mouse)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Early Growth Response Protein 2)
RN  - 0 (Egr2 protein, mouse)
RN  - 0 (Egr3 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 144516-98-3 (Early Growth Response Protein 3)
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-cbl)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
EIN - Nat Immunol. 2005 Jul;6(7):737
MH  - Adaptor Proteins, Signal Transducing/metabolism
MH  - Animals
MH  - Cells, Cultured
MH  - Clonal Anergy/immunology
MH  - DNA-Binding Proteins/deficiency/genetics/*metabolism
MH  - Early Growth Response Protein 2
MH  - Early Growth Response Protein 3
MH  - Gene Expression
MH  - *Lymphocyte Activation/immunology
MH  - Mice
MH  - Mice, Knockout
MH  - Mutation/genetics
MH  - Oligonucleotide Array Sequence Analysis
MH  - Proto-Oncogene Proteins c-cbl
MH  - T-Lymphocytes/cytology/*immunology
MH  - Transcription Factors/deficiency/genetics/*metabolism
MH  - Ubiquitin-Protein Ligases/metabolism
MH  - Up-Regulation
EDAT- 2005/04/19 09:00
MHDA- 2005/05/17 09:00
CRDT- 2005/04/19 09:00
PHST- 2004/12/23 00:00 [received]
PHST- 2005/03/10 00:00 [accepted]
PHST- 2005/04/19 09:00 [pubmed]
PHST- 2005/05/17 09:00 [medline]
PHST- 2005/04/19 09:00 [entrez]
AID - ni1193 [pii]
AID - 10.1038/ni1193 [doi]
PST - ppublish
SO  - Nat Immunol. 2005 May;6(5):472-80. doi: 10.1038/ni1193. Epub 2005 Apr 17.