PMID- 15834502
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20161124
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 57
IP  - 2
DP  - 2005 Apr 25
TI  - Different firing patterns induced by veratridine and aconitine in injured dorsal 
      root ganglion neurons.
PG  - 169-74
AB  - Ectopic spontaneous activity originated from the injured dorsal root ganglion 
      (DRG) neurons in rats was recorded through single dorsal root fiber. The firing 
      patterns induced by veratridine and aconitine, inhibitors of inactivation gate of 
      sodium channel operating on different binding sites, were compared. In the same 
      neuron, veratridine (1.5 approximately 5.0 micromol/L) caused slow wave 
      oscillations of interspike intervals (ISIs), while aconitine (10 approximately 
      200 micromol/L) caused tonic firing. Moreover, even if the background firing 
      patterns were various and the reagent concentrations used were different, 
      veratridine and aconitine still induced slow wave oscillations and tonic firing 
      patterns, respectively. The results suggest that veratridine and aconitine induce 
      different firing patterns in injured DRG neurons, which may relate to their 
      inhibitory effects on different binding sites of the sodium channel.
FAU - Duan, Jian-Hong
AU  - Duan JH
AD  - Institute of Neuroscience, The Fourth Military Medical University, Xi'an 710032, 
      China.
FAU - Xing, Jun-Ling
AU  - Xing JL
FAU - Yang, Jing
AU  - Yang J
FAU - Hu, San-Jue
AU  - Hu SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Sodium Channel Agonists)
RN  - 0 (Sodium Channels)
RN  - 71-62-5 (Veratridine)
RN  - X8YN71D5WC (Aconitine)
SB  - IM
MH  - Aconitine/*pharmacology
MH  - Animals
MH  - Electrophysiological Phenomena/physiology
MH  - Female
MH  - Ganglia, Spinal/injuries/*physiopathology
MH  - Male
MH  - Neurons/pathology/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sodium Channel Agonists
MH  - Sodium Channels/*physiology
MH  - Veratridine/*pharmacology
EDAT- 2005/04/19 09:00
MHDA- 2012/06/29 06:00
CRDT- 2005/04/19 09:00
PHST- 2005/04/19 09:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
PHST- 2005/04/19 09:00 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 2005 Apr 25;57(2):169-74.