PMID- 15836432
OWN - NLM
STAT- MEDLINE
DCOM- 20050818
LR  - 20161020
IS  - 0248-4900 (Print)
IS  - 0248-4900 (Linking)
VI  - 97
IP  - 5
DP  - 2005 May
TI  - Tumour necrosis factor alpha-induced adipose-related protein (TIARP): 
      co-localization with caveolin-1.
PG  - 339-47
AB  - We previously identified TIARP (TNF(alpha)-induced adipose-related protein, where 
      TNF(alpha) stands for tumour necrosis factor alpha), a novel plasma-membrane 
      protein that is induced during 3T3-L1 preadipocytes differentiation by 
      TNF(alpha). Whereas the biological function of TIARP is currently unknown, its 
      protein sequence is reminiscent of transporter protein and/or 
      NAD(P)/NAD(P)H-dependent oxidoreductase activities. We hypothesized that TIARP 
      could be associated with the 3T3-L1 adipocyte plasma-membrane caveolae domains 
      that contain many proteins involved in cellular trafficking and signalling 
      processes. Studies by confocal microscopy showed that TIARP and caveolin-1, a 
      major protein of caveolae, co-localized as patches at the plasma membrane. 
      Immunoblot analysis of cell extracts indicated that TIARP was completely 
      detergent-extractible from membranes, whereas caveolin-1 was present as both 
      detergent-extractible and -insoluble pools. Since TIARP is compartmentalized with 
      caveolin-1 within caveolae domains, we suggest this protein to be part of a 
      signalling complex in association with caveolin-1 and regulatory proteins.
FAU - Chambaut-Guerin, Anne-Marie
AU  - Chambaut-Guerin AM
AD  - Laboratoire de Physiologie et Physiopathologie, Centre de Recherche Biomedicale 
      des Cordeliers, UMR 7079 CNRS-Universite Paris VI, 15 rue de l'Ecole de Medecine, 
      75270 Paris Cedex 06, France. guerin@bhdc.jussieu.fr
FAU - Pairault, Jacques
AU  - Pairault J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biol Cell
JT  - Biology of the cell
JID - 8108529
RN  - 0 (Cav1 protein, mouse)
RN  - 0 (Caveolin 1)
RN  - 0 (Caveolins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Tiarp protein, mouse)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Animals
MH  - Biological Transport/physiology
MH  - Caveolae/*metabolism
MH  - Caveolin 1
MH  - Caveolins/*metabolism
MH  - Membrane Proteins/*metabolism
MH  - Mice
MH  - Signal Transduction/physiology
EDAT- 2005/04/20 09:00
MHDA- 2005/08/19 09:00
CRDT- 2005/04/20 09:00
PHST- 2005/04/20 09:00 [pubmed]
PHST- 2005/08/19 09:00 [medline]
PHST- 2005/04/20 09:00 [entrez]
AID - BC20040062 [pii]
AID - 10.1042/BC20040062 [doi]
PST - ppublish
SO  - Biol Cell. 2005 May;97(5):339-47. doi: 10.1042/BC20040062.