PMID- 15836703
OWN - NLM
STAT- MEDLINE
DCOM- 20050802
LR  - 20221207
IS  - 0815-9319 (Print)
IS  - 0815-9319 (Linking)
VI  - 20
IP  - 4
DP  - 2005 Apr
TI  - Association of fulminant non-A non-B hepatitis with homozygosity for HLA 
      A1-B8-DR3.
PG  - 555-61
AB  - BACKGROUND: For the majority of cases of acute liver failure in western Europe 
      and North America an etiology cannot be defined. The condition is most often 
      called fulminant non-A, non-B (NANB) hepatitis. Features such as female 
      preponderance and presence of serum autoantibodies suggest a possible autoimmune 
      basis. The aim of the present paper was to examine a possible human leukocyte 
      antigen (HLA) association with fulminant NANB hepatitis. METHODS: HLA A, B, and 
      DR data of 55 adult Caucasian fulminant NANB patients were compared with those of 
      1449 local Caucasian controls. RESULTS: In Caucasian patients, homozygosity (but 
      not heterozygosity) for the alleles A1, B8, and DR3 were associated with 
      fulminant NANB hepatitis (Pcorrected = 0.02, <0.00001 and 0.002, respectively). 
      Greatest relative risk (RR) was associated with homozygosity for the A1-B8-DR3 
      haplotype (P < 0.00001; RR: 12.8; 95% confidence interval [CI]: 5.7-22.3). HLA 
      DR8 was also associated with development of the syndrome (RR: 4.2; 95%CI: 
      1.6-9.2). CONCLUSIONS: Homozygosity for the HLA haplotype A1-B8-DR3 confers 
      susceptibility to the development of fulminant NANB hepatitis. This observation 
      may imply a role for the immune response genes (which are flanked by HLA B and 
      DR) in the pathogenesis of this syndrome.
FAU - Gow, Paul
AU  - Gow P
AD  - Gastroenterology Unit and Liver Transplant Unit, Austin Hospital, Heidelberg, 
      Victoria, Australia. Paul.Gow@austin.org.au
FAU - Hathaway, Mark
AU  - Hathaway M
FAU - Gunson, Bridget
AU  - Gunson B
FAU - Heward, Joanne
AU  - Heward J
FAU - Mutimer, David
AU  - Mutimer D
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Hepatitis C/*genetics/*immunology
MH  - Homozygote
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Liver Transplantation
MH  - Male
MH  - Polymerase Chain Reaction
MH  - White People
EDAT- 2005/04/20 09:00
MHDA- 2005/08/03 09:00
CRDT- 2005/04/20 09:00
PHST- 2005/04/20 09:00 [pubmed]
PHST- 2005/08/03 09:00 [medline]
PHST- 2005/04/20 09:00 [entrez]
AID - JGH3605 [pii]
AID - 10.1111/j.1440-1746.2005.03605.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2005 Apr;20(4):555-61. doi: 
      10.1111/j.1440-1746.2005.03605.x.