PMID- 15837259
OWN - NLM
STAT- MEDLINE
DCOM- 20050512
LR  - 20220408
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 45
IP  - 8
DP  - 2005 Apr 19
TI  - Radiofrequency catheter ablation of premature ventricular complexes from right 
      ventricular outflow tract improves left ventricular dilation and clinical status 
      in patients without structural heart disease.
PG  - 1259-65
AB  - OBJECTIVES: The present study evaluated clinical benefits of radiofrequency 
      catheter ablation (RFA) for premature ventricular complexes from right 
      ventricular outflow tract (RVOT-PVC) in patients without structural heart 
      disease. BACKGROUND: It is unknown whether PVC causes left ventricular (LV) 
      dilation, which is a well-recognized precursor of LV dysfunction and heart 
      failure, and whether eliminating PVC by RFA produces clinical benefits in 
      patients with RVOT-PVC. METHODS: Frequency of PVC per total heart beats by 24-h 
      Holter monitoring, left ventricular ejection fraction (LVEF), left ventricular 
      end-diastolic internal dimension (LVDd), mitral regurgitation (MR) by 
      echocardiogram, cardiothoracic ratio (CTR) by chest radiogram, and New York Heart 
      Association (NYHA) functional class of 40 patients with RVOT-PVC without 
      structural heart disease were evaluated before and 6 to 12 months after RFA. 
      RESULTS: Before RFA, a subgroup of patients with frequent (>20%) PVC demonstrated 
      significantly enlarged LVDd and CTR, reduced LVEF, increased MR, and deteriorated 
      NYHA functional class as compared to the subgroup with rare (<20%) PVC (54 +/- 1 
      mm vs. 45 +/- 1 mm, 52 +/- 2% vs. 46 +/- 1%, 66 +/- 2% vs. 73 +/- 2%, 1.2 +/- 0.2 
      degree vs. 0.4 +/- 0.1 degree, and 1.8 +/- 0.2 vs. 1.3 +/- 0.1, respectively; p < 
      0.05). Furthermore, ablating RVOT-PVC readily produced the improvement of all 
      these abnormalities (47 +/- 1 mm, 41 +/- 1%, 72 +/- 2%, 0.3 +/- 0.1 degree, and 
      1.0 +/- 0.0, respectively; p < 0.05 compared with before RFA). CONCLUSIONS: These 
      findings suggest that frequent (>20%) RVOT-PVC may be a possible cause of LV 
      dysfunction and/or heart failure, and RFA produces clinical benefits in these 
      patients.
FAU - Takemoto, Masao
AU  - Takemoto M
AD  - Internal Medicine, Kyushu Kosei-Nenkin Hospital, Kitakyushu, Japan. 
      matakemo@aol.com
FAU - Yoshimura, Hitoshi
AU  - Yoshimura H
FAU - Ohba, Yurika
AU  - Ohba Y
FAU - Matsumoto, Yasuharu
AU  - Matsumoto Y
FAU - Yamamoto, Umpei
AU  - Yamamoto U
FAU - Mohri, Masahiro
AU  - Mohri M
FAU - Yamamoto, Hideo
AU  - Yamamoto H
FAU - Origuchi, Hideki
AU  - Origuchi H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
CIN - J Am Coll Cardiol. 2005 Apr 19;45(8):1266-8. PMID: 15837260
MH  - *Catheter Ablation
MH  - Echocardiography
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Heart Failure/etiology
MH  - Heart Ventricles
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Radiography, Thoracic
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/etiology
MH  - Ventricular Premature Complexes/*surgery
EDAT- 2005/04/20 09:00
MHDA- 2005/05/13 09:00
CRDT- 2005/04/20 09:00
PHST- 2004/10/09 00:00 [received]
PHST- 2004/12/02 00:00 [revised]
PHST- 2004/12/06 00:00 [accepted]
PHST- 2005/04/20 09:00 [pubmed]
PHST- 2005/05/13 09:00 [medline]
PHST- 2005/04/20 09:00 [entrez]
AID - S0735-1097(05)00235-4 [pii]
AID - 10.1016/j.jacc.2004.12.073 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2005 Apr 19;45(8):1259-65. doi: 10.1016/j.jacc.2004.12.073.