PMID- 15840222
OWN - NLM
STAT- MEDLINE
DCOM- 20050902
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 44
IP  - 2
DP  - 2005 Feb
TI  - [A clinical study of hyperhomocysteinemia in rheumatological diseases].
PG  - 111-4
AB  - OBJECTIVE: To analysis plasma homocysteine (Hcy) level and some relative factors 
      in some rheumatological diseases. METHODS: 54 cases with systemic lupus 
      erythematosus (SLE), 48 cases with rheumatoid arthritis (RA), 60 cases with 
      ankylosing spondylitis (AS), 30 cases with undifferentiated spondyloarthropathy 
      (uSpA) and 62 controls were recruited to participate the study. Plasma Hcy, 
      vitamin B(12), folate and the MTHFR gene C677T polymorphism were measured in all 
      patients and controls. RESULTS: (1) Plasma Hcy levels were higher significantly 
      in all disease groups than in the controls, the mean plasma Hcy level was (19.04 
      +/- 6.86) micromol/L for SLE, (19.07 +/- 7.43) micromol/L for RA, (16.47 +/- 
      6.50) micromol/L for AS, (16.59 +/- 6.72) micromol/L for uSpA and (12.24 +/- 
      3.58) micromol/L for controls (P < 0.01). (2) Significant inverse correlation was 
      found between plasma Hcy level and vitamin B(12), folate (r = -0.701, -0.443, 
      respectively; P < 0.01). (3) The MTHFR gene mutation make Hcy level dramatically 
      rise, CC genotype (13.41 +/- 5.78) micromol/L, CT genotype (16.81 +/- 4.22) 
      micromol/L, TT genotype (20.88 +/- 6.60) micromol/L (P < 0.05). TT genotype is 
      susceptible for hyperhomocysteinemia and SLE (OR = 84.46, 7.56 respectively; P < 
      0.05). CONCLUSIONS: (1) Hyperhomocysteinemia is found in most SLE, RA, AS and 
      uSpA patients. (2) There are lots of factors associated with Hcy concentration, 
      such as folate, vitamin B12 and MTHFR gene mutation. (3) TT genotype of MTHFR is 
      susceptible for hyperhomocysteinemia and SLE.
FAU - Xu, Xiao-yan
AU  - Xu XY
AD  - Department of Rheumatology, Zhongda Hospital of Southeast University, Nanjing, 
      Jangsu 210009, China. xiaoyanxu111@sohu.com
FAU - Zhou, Wei-hua
AU  - Zhou WH
FAU - Xiao, Chuan-shi
AU  - Xiao CS
FAU - Li, Xiao-feng
AU  - Li XF
FAU - Wang, Lai-yuan
AU  - Wang LY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Folic Acid/blood
MH  - Genotype
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*etiology/genetics
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Rheumatic Diseases/blood/*complications/genetics
MH  - Vitamin B 12/blood
EDAT- 2005/04/21 09:00
MHDA- 2005/09/03 09:00
CRDT- 2005/04/21 09:00
PHST- 2005/04/21 09:00 [pubmed]
PHST- 2005/09/03 09:00 [medline]
PHST- 2005/04/21 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2005 Feb;44(2):111-4.