PMID- 15841305
OWN - NLM
STAT- MEDLINE
DCOM- 20050913
LR  - 20220227
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 93
IP  - 4
DP  - 2005 Apr
TI  - Thrombolytic agents.
PG  - 627-30
AB  - Thrombolytic agents are plasminogen activators that convert the zymogen 
      plasminogen to the active enzyme plasmin, which degrades fibrin. Elucidation of 
      the molecular mechanism of physiological fibrinolysis opened up a new era of 
      fibrin-specific thrombolysis. Fibrin-specific plasminogen activators, including 
      tissue-type plasminogen activator (t-PA), single-chain urokinase-type plasminogen 
      activator (scu-PA) and staphylokinase (Sak), preferentially activate 
      fibrin-associated plasminogen. Generated plasmin remains associated with fibrin, 
      where it is protected from rapid inhibition and can efficiently degrade fibrin, 
      avoiding systemic activation of the fibrinolytic system. Following a decade of 
      clinical investigation t-PA and variants thereof are routinely used for treatment 
      of patients with thromboembolic disease.
FAU - Collen, Desire
AU  - Collen D
AD  - Center for Molecular and Vascular Biology, KU Leuven, Herestraat 49, B-3000 
      Leuven, Belgium. desire.collen@med.kuleuven.ac.be
FAU - Lijnen, H Roger
AU  - Lijnen HR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Fibrinolytic Agents)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
RN  - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.29 (auR protein, Staphylococcus aureus)
SB  - IM
MH  - Fibrinolytic Agents/*chemistry/metabolism/therapeutic use
MH  - Humans
MH  - Metalloendopeptidases/chemistry/metabolism/therapeutic use
MH  - Tissue Plasminogen Activator/chemistry/metabolism/therapeutic use
MH  - Urokinase-Type Plasminogen Activator/chemistry/metabolism/therapeutic use
RF  - 51
EDAT- 2005/04/21 09:00
MHDA- 2005/09/15 09:00
CRDT- 2005/04/21 09:00
PHST- 2005/04/21 09:00 [pubmed]
PHST- 2005/09/15 09:00 [medline]
PHST- 2005/04/21 09:00 [entrez]
AID - 05040627 [pii]
AID - 10.1160/TH04-11-0724 [doi]
PST - ppublish
SO  - Thromb Haemost. 2005 Apr;93(4):627-30. doi: 10.1160/TH04-11-0724.