PMID- 15841673
OWN - NLM
STAT- MEDLINE
DCOM- 20050524
LR  - 20151119
IS  - 0021-4884 (Print)
IS  - 0021-4884 (Linking)
VI  - 54
IP  - 1
DP  - 2005 Jan
TI  - [The small airway inflammation of asthmatic patients who have used dry powder 
      type inhaled steroid for moderate-long term evaluated by induced sputum and the 
      efficacy of HFA-BDP (QVAR) inhalation].
PG  - 24-35
AB  - Although the dry powder type inhaled steroids, such as Fluticasone Propionate 
      Diskhaler (FP-DH), FP Diskus (FP-DK), Budesonide Turbuhaler (BUD-TH), are widely 
      distributed in daily clinical fields, we clinicians are required to evaluate 
      whether it is effectively inhibiting inflammation of distal airway or not. We 
      also investigated the effect of Hydrofluoroalukan-beclomethasone dipropionate 
      (HFA-BDP), a new type of inhaled steroid which forms super micro aerosol 
      particles, in the distal small airway. METHOD: 85 patients with moderate asthma, 
      who daily used dry powder type inhaled steroid for at least more than 6 months 
      with stable asthmatic condition, were the subject of this study. All subjects 
      underwent sputum induction with the inhalation of 10% of hypertonic saline 
      solution for 15 min and eosinophil counts and eosinophil cationic protein (ECP) 
      in individual induced sputum were measured. Then, patients who had eosinophils 
      detected in their induced sputum changed their previously inhaled steroid to 
      HFA-BDP inhalation (400 i.g./day). Their eosinophil counts and the values of 
      eosinophil cationic protein (ECP), Eotaxin, RANTES and neutrophil elastase 
      (PMN-E) in their induced sputum were also examined before and 4weeks after 
      changing HFA-BDP inhalation. RESULT: Increased eosinophils were found in the 
      induced sputum of 40.5% patients of the FP-DK group, 36.3% of the FP-DH group and 
      32.4% of the BUD-TH group, respectively. Compared with group of patients in which 
      no sputum eosinophil were detected, the sputum ECP values, in which sputum 
      eosinophils were detected, were significantly high. 4 weeks after changing to 
      HFA-BDP inhalation, eosinophil counts, ECP, Eotaxin, RANTES and PMN-E in their 
      induced sputum were decreased in every group. CONCLUSION: Compared with the 
      ordinary dry powder type inhaled steroids, HFA-BDP can effectively diminish 
      distal airway inflammation, suggesting the possibility that HFA-BDP can 
      effectively reach to the distal small airway by forming super micro aerosol 
      particles.
FAU - Ohbayashi, Hiroyuki
AU  - Ohbayashi H
AD  - Internal Medicine, JA Gifu Thono-Kousei Hospital. ohbayasi@nn.iij4u.or.jp
LA  - jpn
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Arerugi
JT  - Arerugi = [Allergy]
JID - 0241212
RN  - 0 (Androstadienes)
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Hydrocarbons, Fluorinated)
RN  - 0 (Powders)
RN  - 51333-22-3 (Budesonide)
RN  - CUT2W21N7U (Fluticasone)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
RN  - KGZ1SLC28Z (Beclomethasone)
SB  - IM
MH  - Administration, Inhalation
MH  - Aged
MH  - Androstadienes/administration & dosage
MH  - Anti-Asthmatic Agents/*administration & dosage
MH  - Asthma/*drug therapy/metabolism
MH  - Beclomethasone/*administration & dosage
MH  - Budesonide/administration & dosage
MH  - Eosinophil Cationic Protein/*metabolism
MH  - Eosinophils
MH  - Female
MH  - Fluticasone
MH  - Humans
MH  - Hydrocarbons, Fluorinated/administration & dosage
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Powders
MH  - Sputum/cytology/*metabolism
EDAT- 2005/04/22 09:00
MHDA- 2005/05/25 09:00
CRDT- 2005/04/22 09:00
PHST- 2005/04/22 09:00 [pubmed]
PHST- 2005/05/25 09:00 [medline]
PHST- 2005/04/22 09:00 [entrez]
PST - ppublish
SO  - Arerugi. 2005 Jan;54(1):24-35.