PMID- 15842229
OWN - NLM
STAT- MEDLINE
DCOM- 20060131
LR  - 20050421
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 60 Suppl 79
DP  - 2005
TI  - Food allergy--accurately identifying clinical reactivity.
PG  - 19-24
AB  - Up to 25% of adults believe that they or their children are afflicted with a food 
      allergy. However, the actual prevalence of food allergy is much lower: 
      approximately 6-8% of children suffer from food allergy during their first 3 
      years of life, and many children then develop clinical tolerance. Food allergy 
      encompasses a whole spectrum of disorders, with symptoms that may be cutaneous, 
      gastrointestinal or respiratory in nature. Food disorders also differ according 
      to the extent that they are immunoglobulin E (IgE)-mediated. Skin-prick testing 
      is often used to identify food sensitization, although double-blind, 
      placebo-controlled food challenge (DBPCFC) tests remain the gold standard for 
      diagnosis. Recent evidence suggests that quantitative IgE measurements can 
      predict the outcome of DBPCFC tests and can replace about half of all oral food 
      challenges. When an extensive medical history is obtained in combination with IgE 
      quantification, even fewer patients may require formal food challenges. It has 
      also become possible to map the IgE-binding regions of many major food allergens. 
      This may help to identify children with persistent food allergy, as opposed to 
      those who may develop clinical tolerance. In future, microarray technology may 
      enable physicians to screen patients for a large number of food proteins and 
      epitopes, using just a few drops of blood.
FAU - Sampson, H A
AU  - Sampson HA
AD  - Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Epitopes)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Antibody Specificity
MH  - Child
MH  - Child, Preschool
MH  - Epitopes/immunology
MH  - Food Hypersensitivity/blood/*diagnosis/epidemiology
MH  - Humans
MH  - Hypersensitivity, Delayed/blood/diagnosis
MH  - Immunoglobulin E/blood
MH  - Immunologic Tests
MH  - Prevalence
MH  - Respiratory Hypersensitivity/blood/diagnosis
RF  - 42
EDAT- 2005/04/22 09:00
MHDA- 2006/02/01 09:00
CRDT- 2005/04/22 09:00
PHST- 2005/04/22 09:00 [pubmed]
PHST- 2006/02/01 09:00 [medline]
PHST- 2005/04/22 09:00 [entrez]
AID - ALL853 [pii]
AID - 10.1111/j.1398-9995.2005.00853.x [doi]
PST - ppublish
SO  - Allergy. 2005;60 Suppl 79:19-24. doi: 10.1111/j.1398-9995.2005.00853.x.