PMID- 15842956
OWN - NLM
STAT- MEDLINE
DCOM- 20050930
LR  - 20220716
IS  - 1529-7322 (Print)
IS  - 1529-7322 (Linking)
VI  - 5
IP  - 3
DP  - 2005 May
TI  - The immunoglobulin E receptor: expression and regulation.
PG  - 191-6
AB  - The interaction of immunoglobulin E (IgE) and its receptors is critical for the 
      manifestation of allergic disease. Currently, IgE receptors include the 
      high-affinity Fc epsilonRI and the low-affinity Fc epsilonRII. Fc epsilonRI is a 
      tetrameric or trimeric complex, and each has distinct expression patterns and 
      unique functional consequences. In general, serum levels of IgE regulate Fc 
      epsilonRI expression, and novel therapies that lower the concentration of IgE 
      have provided insights into the contribution of this receptor in allergic 
      disease. Newer therapies targeting Fc epsilonRI-signaling elements and the 
      low-affinity IgE receptor, Fc epsilonRII (CD23), are being developed.
FAU - Conner, Edward R
AU  - Conner ER
AD  - Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.
FAU - Saini, Sarbjit S
AU  - Saini SS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Receptors, IgE)
RN  - 2P471X1Z11 (Omalizumab)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies, Anti-Idiotypic
MH  - Antibodies, Monoclonal/pharmacology
MH  - Antibodies, Monoclonal, Humanized
MH  - Antigen-Presenting Cells/metabolism
MH  - Basophils/metabolism
MH  - Dendritic Cells/metabolism
MH  - Eosinophils/metabolism
MH  - Humans
MH  - Hypersensitivity/immunology/*metabolism
MH  - Immunoglobulin E/blood/immunology/metabolism
MH  - Mast Cells/metabolism
MH  - Omalizumab
MH  - Receptors, IgE/*immunology/*metabolism
RF  - 47
EDAT- 2005/04/22 09:00
MHDA- 2005/10/01 09:00
CRDT- 2005/04/22 09:00
PHST- 2005/04/22 09:00 [pubmed]
PHST- 2005/10/01 09:00 [medline]
PHST- 2005/04/22 09:00 [entrez]
AID - 10.1007/s11882-005-0037-5 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2005 May;5(3):191-6. doi: 10.1007/s11882-005-0037-5.