PMID- 15842961
OWN - NLM
STAT- MEDLINE
DCOM- 20050930
LR  - 20220716
IS  - 1529-7322 (Print)
IS  - 1529-7322 (Linking)
VI  - 5
IP  - 3
DP  - 2005 May
TI  - A new paradigm for immunoglobulin E in allergic diseases.
PG  - 227-32
AB  - Recent observations at the level of the antigen presenting cell, as well as the T 
      cell, point toward a pivotal role for interleukin (IL)-10 in the control of 
      immunoglobulin E (IgE)-mediated allergic diseases, such as asthma and rhinitis. 
      This has led to restructuring of the Th1/Th2 paradigm with IL-10 acting to 
      modulate Th2-driven IgE antibody (Ab) responses. The modified Th2 response to cat 
      allergen is associated with high-dose allergen exposure and the presence of high 
      titer IgG and IgG4 Ab; however, IgE Ab and allergic symptoms are absent. 
      Characteristics of this immune response indicate that it is a variant of the 
      allergic response, which develops in an IL-10-dependent manner, but it is 
      distinct from other types of nonallergic or tolerant responses. These 
      observations point toward a new paradigm for the development of IgE-mediated 
      responses. This may be important for advancing our understanding of the response 
      to immunotherapy and anti-IgE, and for defining immune mechanisms that drive 
      allergic responses.
FAU - Woodfolk, Judith A
AU  - Woodfolk JA
AD  - Asthma and Allergic Diseases Center, University of Virginia Health System, 
      Charlottesville 22908-1355, USA. jaw4m@virginia.edu
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 0 (Glycoproteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - G408EE88II (Fel d 1 protein, Felis domesticus)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/immunology
MH  - Glycoproteins/immunology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/*immunology
MH  - Mice
MH  - Th1 Cells/immunology
MH  - Th2 Cells/*immunology
RF  - 37
EDAT- 2005/04/22 09:00
MHDA- 2005/10/01 09:00
CRDT- 2005/04/22 09:00
PHST- 2005/04/22 09:00 [pubmed]
PHST- 2005/10/01 09:00 [medline]
PHST- 2005/04/22 09:00 [entrez]
AID - 10.1007/s11882-005-0042-8 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2005 May;5(3):227-32. doi: 10.1007/s11882-005-0042-8.