PMID- 15842962
OWN - NLM
STAT- MEDLINE
DCOM- 20050930
LR  - 20220716
IS  - 1529-7322 (Print)
IS  - 1529-7322 (Linking)
VI  - 5
IP  - 3
DP  - 2005 May
TI  - Persistent nonallergic rhinosinusitis.
PG  - 233-42
AB  - Nonallergic rhinitis is a complex of syndromes that are united by the absence of 
      atopic, T(H)2 lymphocyte, immunoglobulin E (IgE)-mediated mechanisms. We propose 
      a classification system based on the presence or absence of inflammatory 
      granulocytes. Eosinophilic nonallergic rhinosinusitis may also be called chronic 
      eosinophilic sinusitis syndromes (CESS) to help classify these disorders in which 
      diverse mechanisms of eosinophil chemoattraction and survival predominate. 
      Allergic fungal sinusitis, eosinophilic nasal polyps, aspirin sensitivity, and 
      related disorders would fit in this category. Accumulation of neutrophils occurs 
      in chronic infectious rhinosinusitis, foreign body reactions, and 
      immunodeficiencies. More complex and variable combinations of leukocytes are 
      found in Wegner's granulomatosis and related syndromes, and during the evolution 
      of viral infections. The noninflammatory disorders can be divided by mechanism 
      into hormonal; sympathetic dysfunction (including antihypertensive adrenergic 
      drug therapy); cholinergic rhinitis; and nociceptive syndromes with hyperalgesia 
      and other features (eg, the nonallergic rhinitis of chronic fatigue syndrome). 
      Therapy based on the most likely pathophysiologic mechanism is anticipated to 
      have the most success, but requires acceptance of the wide differential diagnosis 
      of nonallergic rhinitis and rejection of the obsolete term of "vasomotor 
      rhinitis."
FAU - Staevska, Maria
AU  - Staevska M
AD  - Division of Rheumatology, Immunology and Allergy, Room B105, Georgetown 
      University, Lower Level Kober-Cogan Building, 3800 Reservoir Road, NW, 
      Washington, DC 20007-2197, USA.
FAU - Baraniuk, James N
AU  - Baraniuk JN
LA  - eng
GR  - R01 AI42403/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
SB  - IM
MH  - Diagnosis, Differential
MH  - Humans
MH  - Radioallergosorbent Test
MH  - Rhinitis/classification/*diagnosis/therapy
MH  - Sinusitis/classification/*diagnosis/therapy
MH  - Skin Tests
RF  - 25
EDAT- 2005/04/22 09:00
MHDA- 2005/10/01 09:00
CRDT- 2005/04/22 09:00
PHST- 2005/04/22 09:00 [pubmed]
PHST- 2005/10/01 09:00 [medline]
PHST- 2005/04/22 09:00 [entrez]
AID - 10.1007/s11882-005-0043-7 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2005 May;5(3):233-42. doi: 10.1007/s11882-005-0043-7.